Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse

This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to...

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Publicado:	2015
Materias:	Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n3_p162_Urbano http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19840659_v8_n3_p162_Urbano
record_format	dspace
spelling	paper:paper_19840659_v8_n3_p162_Urbano2023-06-08T16:32:47Z Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n3_p162_Urbano http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation
spellingShingle	Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
topic_facet	Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation
description	This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep.
title	Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
title_short	Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
title_full	Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
title_fullStr	Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
title_full_unstemmed	Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
title_sort	pedunculopontine arousal system(ft physiology—effects of psychostimulant abuse
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n3_p162_Urbano http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano
_version_	1768545713351819264

Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse

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