Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse

This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using mod­ulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado: 2015
Materias:
Amphetamine
Cocaine
Dopamine
Nicotine
P/Q-type calciumchannels T-type calciumchannels
calcium channel
cocaine
nicotine
psychostimulant agent
behavior
human
locomotion
membrane potential
pedunculopontine tegmental nucleus
physiology
Review
sleep arousal disorder
sleep deprivation
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n3_p162_Urbano
http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using mod­ulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep.

Ejemplares similares