Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors

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A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyani...

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Autores principales:	Peinetti, Ana Sol, Gonzalez, Graciela Alicia, Ramirez, Silvana Andrea María, Battaglini, Fernando
Publicado:	2015
Materias:	Alumina Electric conductance Electrochemical impedance spectroscopy Electron transport properties Fiber optic sensors Gold Metal nanoparticles Molecules Nanoparticles Adenosine monophosphate Conducting surfaces Conformational change Controlled architecture Fast electron transfer Label-free detection Small-molecule bindings Uncapped Nanoparticles Synthesis (chemical) adenosine phosphate aluminum oxide aptamer gold metal nanoparticle chemistry impedance nanotechnology porosity procedures Adenosine Monophosphate Aluminum Oxide Aptamers, Nucleotide Electric Impedance Metal Nanoparticles Nanotechnology Porosity
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20403364_v7_n17_p7763_Peinetti http://hdl.handle.net/20.500.12110/paper_20403364_v7_n17_p7763_Peinetti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_20403364_v7_n17_p7763_Peinetti
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spelling	paper:paper_20403364_v7_n17_p7763_Peinetti2025-07-30T19:08:39Z Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors Peinetti, Ana Sol Gonzalez, Graciela Alicia Ramirez, Silvana Andrea María Battaglini, Fernando Alumina Electric conductance Electrochemical impedance spectroscopy Electron transport properties Fiber optic sensors Gold Metal nanoparticles Molecules Nanoparticles Adenosine monophosphate Conducting surfaces Conformational change Controlled architecture Fast electron transfer Label-free detection Small-molecule bindings Uncapped Nanoparticles Synthesis (chemical) adenosine phosphate aluminum oxide aptamer gold metal nanoparticle chemistry impedance nanotechnology porosity procedures Adenosine Monophosphate Aluminum Oxide Aptamers, Nucleotide Electric Impedance Gold Metal Nanoparticles Nanotechnology Porosity A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale. © The Royal Society of Chemistry 2015. Fil:Peinetti, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:González, G.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramírez, S.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Battaglini, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20403364_v7_n17_p7763_Peinetti http://hdl.handle.net/20.500.12110/paper_20403364_v7_n17_p7763_Peinetti
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alumina Electric conductance Electrochemical impedance spectroscopy Electron transport properties Fiber optic sensors Gold Metal nanoparticles Molecules Nanoparticles Adenosine monophosphate Conducting surfaces Conformational change Controlled architecture Fast electron transfer Label-free detection Small-molecule bindings Uncapped Nanoparticles Synthesis (chemical) adenosine phosphate aluminum oxide aptamer gold metal nanoparticle chemistry impedance nanotechnology porosity procedures Adenosine Monophosphate Aluminum Oxide Aptamers, Nucleotide Electric Impedance Gold Metal Nanoparticles Nanotechnology Porosity
spellingShingle	Alumina Electric conductance Electrochemical impedance spectroscopy Electron transport properties Fiber optic sensors Gold Metal nanoparticles Molecules Nanoparticles Adenosine monophosphate Conducting surfaces Conformational change Controlled architecture Fast electron transfer Label-free detection Small-molecule bindings Uncapped Nanoparticles Synthesis (chemical) adenosine phosphate aluminum oxide aptamer gold metal nanoparticle chemistry impedance nanotechnology porosity procedures Adenosine Monophosphate Aluminum Oxide Aptamers, Nucleotide Electric Impedance Gold Metal Nanoparticles Nanotechnology Porosity Peinetti, Ana Sol Gonzalez, Graciela Alicia Ramirez, Silvana Andrea María Battaglini, Fernando Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
topic_facet	Alumina Electric conductance Electrochemical impedance spectroscopy Electron transport properties Fiber optic sensors Gold Metal nanoparticles Molecules Nanoparticles Adenosine monophosphate Conducting surfaces Conformational change Controlled architecture Fast electron transfer Label-free detection Small-molecule bindings Uncapped Nanoparticles Synthesis (chemical) adenosine phosphate aluminum oxide aptamer gold metal nanoparticle chemistry impedance nanotechnology porosity procedures Adenosine Monophosphate Aluminum Oxide Aptamers, Nucleotide Electric Impedance Gold Metal Nanoparticles Nanotechnology Porosity
description	A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale. © The Royal Society of Chemistry 2015.
author	Peinetti, Ana Sol Gonzalez, Graciela Alicia Ramirez, Silvana Andrea María Battaglini, Fernando
author_facet	Peinetti, Ana Sol Gonzalez, Graciela Alicia Ramirez, Silvana Andrea María Battaglini, Fernando
author_sort	Peinetti, Ana Sol
title	Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
title_short	Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
title_full	Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
title_fullStr	Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
title_full_unstemmed	Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
title_sort	confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20403364_v7_n17_p7763_Peinetti http://hdl.handle.net/20.500.12110/paper_20403364_v7_n17_p7763_Peinetti
work_keys_str_mv	AT peinettianasol confinedgoldnanoparticlesenhancethedetectionofsmallmoleculesinlabelfreeimpedanceaptasensors AT gonzalezgracielaalicia confinedgoldnanoparticlesenhancethedetectionofsmallmoleculesinlabelfreeimpedanceaptasensors AT ramirezsilvanaandreamaria confinedgoldnanoparticlesenhancethedetectionofsmallmoleculesinlabelfreeimpedanceaptasensors AT battaglinifernando confinedgoldnanoparticlesenhancethedetectionofsmallmoleculesinlabelfreeimpedanceaptasensors
_version_	1840321726908465152

Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors

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