Information content in stochastic pulse sequences of intracellular messengers

Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmit...

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Guardado en:
Detalles Bibliográficos
Publicado: 2018
Materias:
Ca2+ pulses
Cell signaling
Information
Inhibition
Poisson processes
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_2296424X_v6_nJUL_p_Givre
http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_2296424X_v6_nJUL_p_Givre
record_format dspace
spelling paper:paper_2296424X_v6_nJUL_p_Givre2023-06-08T16:35:25Z Information content in stochastic pulse sequences of intracellular messengers Ca2+ pulses Cell signaling Information Inhibition Poisson processes Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmitters. The analysis of intracellular Ca2+ pulses that involve Ca2+ release through inositol 1,4,5-trisphosphate (IP3) receptors led to a model with stochastic pulse firing at rate, λ and deterministic inhibition with recovery at rate, ρ. Here we combine this model with recent observations that established an exponential relationship between λ and the external ligand concentration, C. We compute analytically the mutual information between C and the interpulse time, t, or the number of pulses, N, in the λ/ρ ≪ 1 and λ/ρ ≫ 1 limits. We obtain that both I(C, t) and I(C, N) are largest in the second limit with a difference of at most ~1bit. Thus, the resolution with which the values of C can be discriminated at most doubles in one limit with respect to the other. The components of the model and the exponential dependence of the firing rate with C are features common to noise-driven excitable systems. Our results thus hold in this more general setting that applies widely in biology. © 2018 Givré and Ponce Dawson. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_2296424X_v6_nJUL_p_Givre http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Ca2+ pulses
Cell signaling
Information
Inhibition
Poisson processes
spellingShingle Ca2+ pulses
Cell signaling
Information
Inhibition
Poisson processes
Information content in stochastic pulse sequences of intracellular messengers
topic_facet Ca2+ pulses
Cell signaling
Information
Inhibition
Poisson processes
description Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmitters. The analysis of intracellular Ca2+ pulses that involve Ca2+ release through inositol 1,4,5-trisphosphate (IP3) receptors led to a model with stochastic pulse firing at rate, λ and deterministic inhibition with recovery at rate, ρ. Here we combine this model with recent observations that established an exponential relationship between λ and the external ligand concentration, C. We compute analytically the mutual information between C and the interpulse time, t, or the number of pulses, N, in the λ/ρ ≪ 1 and λ/ρ ≫ 1 limits. We obtain that both I(C, t) and I(C, N) are largest in the second limit with a difference of at most ~1bit. Thus, the resolution with which the values of C can be discriminated at most doubles in one limit with respect to the other. The components of the model and the exponential dependence of the firing rate with C are features common to noise-driven excitable systems. Our results thus hold in this more general setting that applies widely in biology. © 2018 Givré and Ponce Dawson.
title Information content in stochastic pulse sequences of intracellular messengers
title_short Information content in stochastic pulse sequences of intracellular messengers
title_full Information content in stochastic pulse sequences of intracellular messengers
title_fullStr Information content in stochastic pulse sequences of intracellular messengers
title_full_unstemmed Information content in stochastic pulse sequences of intracellular messengers
title_sort information content in stochastic pulse sequences of intracellular messengers
publishDate 2018
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_2296424X_v6_nJUL_p_Givre
http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre
_version_ 1768544842928881664

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