Drug Abuse and the RAS

Interactions between the pedunculopontine (PPN) and ventral tegmental area (VTA) have been described as key brain circuitry that mediates psychostimulant-mediated reward. Intranuclear PPN/laterodorsal tegmental injections of cholinergic receptor agonists or antagonists have helped clarify the role o...

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Detalles Bibliográficos
Publicado: 2015
Materias:
Amphetamine
Benzodiazepines
Cocaine
Dopamine
Nicotine
Psychostimulant
Tobacco
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p277_Urbano
http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p277_Urbano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_97801280_v_n_p277_Urbano
record_format dspace
spelling paper:paper_97801280_v_n_p277_Urbano2023-06-08T16:37:00Z Drug Abuse and the RAS Amphetamine Benzodiazepines Cocaine Dopamine Nicotine Psychostimulant Tobacco Interactions between the pedunculopontine (PPN) and ventral tegmental area (VTA) have been described as key brain circuitry that mediates psychostimulant-mediated reward. Intranuclear PPN/laterodorsal tegmental injections of cholinergic receptor agonists or antagonists have helped clarify the role of these nuclei on psychostimulant-induced locomotion. Also, nicotine has been shown to have an inhibitory effect on the PPN, at least initially reducing arousal. PPN activation has been involved in the animal's voluntary search for psychostimulants. On the other hand, CNS depressants like ethanol might reduce arousal by a mechanism involving the direct inhibition of the PPN. In conclusion, neural activity in the PPN is key not only to maintaining arousal but also to affecting the level of psychostimulant and depressant administration. © 2015 Elsevier Inc. All rights reserved. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p277_Urbano http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p277_Urbano
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Amphetamine
Benzodiazepines
Cocaine
Dopamine
Nicotine
Psychostimulant
Tobacco
spellingShingle Amphetamine
Benzodiazepines
Cocaine
Dopamine
Nicotine
Psychostimulant
Tobacco
Drug Abuse and the RAS
topic_facet Amphetamine
Benzodiazepines
Cocaine
Dopamine
Nicotine
Psychostimulant
Tobacco
description Interactions between the pedunculopontine (PPN) and ventral tegmental area (VTA) have been described as key brain circuitry that mediates psychostimulant-mediated reward. Intranuclear PPN/laterodorsal tegmental injections of cholinergic receptor agonists or antagonists have helped clarify the role of these nuclei on psychostimulant-induced locomotion. Also, nicotine has been shown to have an inhibitory effect on the PPN, at least initially reducing arousal. PPN activation has been involved in the animal's voluntary search for psychostimulants. On the other hand, CNS depressants like ethanol might reduce arousal by a mechanism involving the direct inhibition of the PPN. In conclusion, neural activity in the PPN is key not only to maintaining arousal but also to affecting the level of psychostimulant and depressant administration. © 2015 Elsevier Inc. All rights reserved.
title Drug Abuse and the RAS
title_short Drug Abuse and the RAS
title_full Drug Abuse and the RAS
title_fullStr Drug Abuse and the RAS
title_full_unstemmed Drug Abuse and the RAS
title_sort drug abuse and the ras
publishDate 2015
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p277_Urbano
http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p277_Urbano
_version_ 1768544662099853312

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