Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure
Background: Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin α-subunit (INHα) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. Methods: Polymorphism -16 C>T of INHα gene was studied in 61 POF p...
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| Formato: | Artículo publishedVersion |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_02681161_v21_n5_p1154_Sundblad |
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paperaa:paper_02681161_v21_n5_p1154_Sundblad2023-06-12T16:47:11Z Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure Hum. Reprod. 2006;21(5):1154-1160 Sundblad, V. Chiauzzi, V.A. Andreone, L. Campo, S. Charreau, E.H. Dain, L. Inhibin levels Inhibin α-subunit gene Premature ovarian failure cytosine follitropin inhibin inhibin A inhibin B thymine adult allele alpha chain amenorrhea article confidence interval controlled study DNA polymorphism female follicular phase genotype heterozygosity human major clinical study negative feedback nucleic acid base substitution premature ovarian failure risk assessment statistical analysis Background: Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin α-subunit (INHα) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. Methods: Polymorphism -16 C>T of INHα gene was studied in 61 POF patients and 82 controls above 40 years old (C > 40). Substitution 769G>A was studied in 59 POF patients, 76 C > 40 and 73 controls below 40 years old (C < 40). Results: No significant difference in risk of POF development for -16T allele was found when comparing idiopathic POF (I-POF) with C > 40 (Odds ratio = 1.46; 95% confidence interval = 0.63-3.19). Implication of -16C>T polymorphism in serum inhibin levels was analysed in 46 controls, and no significant differences (P > 0.05) were found between CC and CT + TT genotype groups when comparing either mid-follicular phase Pro-αC and inhibin B values or mid-luteal phase Pro-αC and inhibin A values. Heterozygosity for substitution 769G>A was found in 1 of 59 POF woman, 2 of 76 C > 40 and 6 of 73 C < 40. Presence of this su bstitution in a relevant number of control subjects is herein described for the first time. Conclusion: Our results indicate that -16C>T and 769G>A variants in INHα gene may not be associated to POF disease. © 2006 Oxford University Press. Fil:Sundblad, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Charreau, E.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02681161_v21_n5_p1154_Sundblad |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Inhibin levels Inhibin α-subunit gene Premature ovarian failure cytosine follitropin inhibin inhibin A inhibin B thymine adult allele alpha chain amenorrhea article confidence interval controlled study DNA polymorphism female follicular phase genotype heterozygosity human major clinical study negative feedback nucleic acid base substitution premature ovarian failure risk assessment statistical analysis |
| spellingShingle |
Inhibin levels Inhibin α-subunit gene Premature ovarian failure cytosine follitropin inhibin inhibin A inhibin B thymine adult allele alpha chain amenorrhea article confidence interval controlled study DNA polymorphism female follicular phase genotype heterozygosity human major clinical study negative feedback nucleic acid base substitution premature ovarian failure risk assessment statistical analysis Sundblad, V. Chiauzzi, V.A. Andreone, L. Campo, S. Charreau, E.H. Dain, L. Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| topic_facet |
Inhibin levels Inhibin α-subunit gene Premature ovarian failure cytosine follitropin inhibin inhibin A inhibin B thymine adult allele alpha chain amenorrhea article confidence interval controlled study DNA polymorphism female follicular phase genotype heterozygosity human major clinical study negative feedback nucleic acid base substitution premature ovarian failure risk assessment statistical analysis |
| description |
Background: Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin α-subunit (INHα) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. Methods: Polymorphism -16 C>T of INHα gene was studied in 61 POF patients and 82 controls above 40 years old (C > 40). Substitution 769G>A was studied in 59 POF patients, 76 C > 40 and 73 controls below 40 years old (C < 40). Results: No significant difference in risk of POF development for -16T allele was found when comparing idiopathic POF (I-POF) with C > 40 (Odds ratio = 1.46; 95% confidence interval = 0.63-3.19). Implication of -16C>T polymorphism in serum inhibin levels was analysed in 46 controls, and no significant differences (P > 0.05) were found between CC and CT + TT genotype groups when comparing either mid-follicular phase Pro-αC and inhibin B values or mid-luteal phase Pro-αC and inhibin A values. Heterozygosity for substitution 769G>A was found in 1 of 59 POF woman, 2 of 76 C > 40 and 6 of 73 C < 40. Presence of this su bstitution in a relevant number of control subjects is herein described for the first time. Conclusion: Our results indicate that -16C>T and 769G>A variants in INHα gene may not be associated to POF disease. © 2006 Oxford University Press. |
| format |
Artículo Artículo publishedVersion |
| author |
Sundblad, V. Chiauzzi, V.A. Andreone, L. Campo, S. Charreau, E.H. Dain, L. |
| author_facet |
Sundblad, V. Chiauzzi, V.A. Andreone, L. Campo, S. Charreau, E.H. Dain, L. |
| author_sort |
Sundblad, V. |
| title |
Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| title_short |
Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| title_full |
Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| title_fullStr |
Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| title_full_unstemmed |
Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| title_sort |
controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure |
| publishDate |
2006 |
| url |
http://hdl.handle.net/20.500.12110/paper_02681161_v21_n5_p1154_Sundblad |
| work_keys_str_mv |
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| _version_ |
1769810030385692672 |