Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection

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Fil: Martorelli, L. Instituto de Patobiología, CICVyA, INTA, Hurlingham, Argentina.

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Autores principales: Martorelli, L., Hovde, C. J., Vilte, Daniel A., Albanese, A., Zotta, E., Ibarra, C., Cantet, Rodolfo Juan Carlos, Mercado, Elsa C., Cataldi, Angel Adrián
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2015
Materias:
ESCHERICHIA COLI
HAEMOLYTIC UREMIC SYNDROME
BACTERIA
Acceso en línea:http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2015martorelli
Aporte de:
FAUBA Digital - Facultad de Agronomía (UBA) de Universidad de Buenos Aires
id snrd:2015martorelli
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spelling snrd:2015martorelli2021-10-15T16:56:07Z Martorelli, L. Hovde, C. J. Vilte, Daniel A. Albanese, A. Zotta, E. Ibarra, C. Cantet, Rodolfo Juan Carlos Mercado, Elsa C. Cataldi, Angel Adrián 2015 Fil: Martorelli, L. Instituto de Patobiología, CICVyA, INTA, Hurlingham, Argentina. Fil: Hovde, C. J. School of Food Science, University of Idaho, Moscow, USA. Fil: Vilte, Daniel A. Instituto de Patobiología, CICVyA, INTA, Hurlingham, Argentina. Fil: Albanese, A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología. Laboratorio de Fisiopatogenia. Buenos Aires, Argentina. Fil: Zotta, E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología. Laboratorio de Fisiopatogenia. Buenos Aires, Argentina. Fil: Ibarra, C. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología. Laboratorio de Fisiopatogenia. Buenos Aires, Argentina. Fil: Cantet, Rodolfo Juan Carlos. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. Fil: Cantet, Rodolfo Juan Carlos. CONICET. Buenos Aires, Argentina. Fil: Mercado, Elsa C. Instituto de Patobiología, CICVyA, INTA, Hurlingham, Argentina. Fil: Cataldi, Angel Adrián. Instituto de Biotecnología, CICVyA, INTA, Hurlingham, Argentina. Escherichia coli O157:H7 is themain causative agent of haemolytic uremic syndrome. Cattle are themain reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with either 108 or 1010 CFU, as well as the ability of specific preexisting antibodies to reduce shedding of the pathogen. Shedding was analysed by direct counting as well as enrichment of rectoanal mucosal swabs. Statistical analysis was performed using a linear model for repeated measures with and without the inclusion of preexisting antibodies against the carboxy - terminal fraction of intimin-. (.-intimin C280) as a covariable. Results suggest that there is a statistical difference in the area under the shedding curves between both doses for 14 as well as 28 days after challenge (p = 0.0069 and 0.0209, resp.). This difference is increased when the prechallenge antibodies are taken into account (p = 0.0056 and 0.0185). We concluded that the bacterial dose influences shedding on calves experimentally challenged and that preexisting antibodies against E. coli O157:H7 .-intimin C280 could partially reduce faecal excretion. application/pdf doi:10.1155/2015/290679 issn: http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2015martorelli eng info:eu-repo/semantics/openAccess openAccess http://ri.agro.uba.ar/greenstone3/library/page/biblioteca#section4 BioMed Research International Vol.2015 Article ID 290679 http://www.hindawi.com ESCHERICHIA COLI HAEMOLYTIC UREMIC SYNDROME BACTERIA Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection info:eu-repo/semantics/article info:ar-repo/semantics/artículo publishedVersion info:eu-repo/semantics/publishedVersion
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-140
collection FAUBA Digital - Facultad de Agronomía (UBA)
language Inglés
orig_language_str_mv eng
topic ESCHERICHIA COLI
HAEMOLYTIC UREMIC SYNDROME
BACTERIA
spellingShingle ESCHERICHIA COLI
HAEMOLYTIC UREMIC SYNDROME
BACTERIA
Martorelli, L.
Hovde, C. J.
Vilte, Daniel A.
Albanese, A.
Zotta, E.
Ibarra, C.
Cantet, Rodolfo Juan Carlos
Mercado, Elsa C.
Cataldi, Angel Adrián
Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
topic_facet ESCHERICHIA COLI
HAEMOLYTIC UREMIC SYNDROME
BACTERIA
description Fil: Martorelli, L. Instituto de Patobiología, CICVyA, INTA, Hurlingham, Argentina.
format Artículo
Artículo
publishedVersion
publishedVersion
author Martorelli, L.
Hovde, C. J.
Vilte, Daniel A.
Albanese, A.
Zotta, E.
Ibarra, C.
Cantet, Rodolfo Juan Carlos
Mercado, Elsa C.
Cataldi, Angel Adrián
author_facet Martorelli, L.
Hovde, C. J.
Vilte, Daniel A.
Albanese, A.
Zotta, E.
Ibarra, C.
Cantet, Rodolfo Juan Carlos
Mercado, Elsa C.
Cataldi, Angel Adrián
author_sort Martorelli, L.
title Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
title_short Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
title_full Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
title_fullStr Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
title_full_unstemmed Impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on Escherichia coli O157:H7 shedding in calves following experimental Infection
title_sort impact of infection dose and previous serum antibodies against the locus of enterocyte effacement proteins on escherichia coli o157:h7 shedding in calves following experimental infection
publishDate 2015
url http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2015martorelli
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