The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine

The accumulation of argininosuccinate by an arg-10 mutant of Neurospora crassa is enhanced when growth-limiting amounts of arginine are used, or when citrulline is supplied in addition to non-limiting concentrations of arginine. Elevated levels of ornithine carbamoyl transferase (carbamoyl phosphate...

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Detalles Bibliográficos
Autor principal: Nazario, M.
Formato: JOUR
Materias:
arginine
citrulline
ornithine carbamoyltransferase
article
metabolism
mutation
Neurospora
paper chromatography
Arginine
Chromatography, Paper
Citrulline
Mutation
Ornithine Carbamoyltransferase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00052787_v145_n1_p138_Nazario
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00052787_v145_n1_p138_Nazario2023-10-03T14:03:31Z The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine Nazario, M. arginine citrulline ornithine carbamoyltransferase article metabolism mutation Neurospora paper chromatography Arginine Chromatography, Paper Citrulline Mutation Neurospora Ornithine Carbamoyltransferase The accumulation of argininosuccinate by an arg-10 mutant of Neurospora crassa is enhanced when growth-limiting amounts of arginine are used, or when citrulline is supplied in addition to non-limiting concentrations of arginine. Elevated levels of ornithine carbamoyl transferase (carbamoyl phosphate: l-ornithine carbamoyl transferase, EC 2.1.3.3) are found under circumstances leading to accumulation of argininosuccinate. An explanation based on the possibility that citrulline might impose a limited availability of arginine has been excluded. Indeed, the mutant displays a higher mycelial pool of arginine, and an increased consumption of this amino acid when it is grown with added citrulline. It is emphasized that elevated (derepressed) levels of ornithine carbamoyl transferase prevail under these conditions. © 1967. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00052787_v145_n1_p138_Nazario
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic arginine
citrulline
ornithine carbamoyltransferase
article
metabolism
mutation
Neurospora
paper chromatography
Arginine
Chromatography, Paper
Citrulline
Mutation
Neurospora
Ornithine Carbamoyltransferase
spellingShingle arginine
citrulline
ornithine carbamoyltransferase
article
metabolism
mutation
Neurospora
paper chromatography
Arginine
Chromatography, Paper
Citrulline
Mutation
Neurospora
Ornithine Carbamoyltransferase
Nazario, M.
The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
topic_facet arginine
citrulline
ornithine carbamoyltransferase
article
metabolism
mutation
Neurospora
paper chromatography
Arginine
Chromatography, Paper
Citrulline
Mutation
Neurospora
Ornithine Carbamoyltransferase
description The accumulation of argininosuccinate by an arg-10 mutant of Neurospora crassa is enhanced when growth-limiting amounts of arginine are used, or when citrulline is supplied in addition to non-limiting concentrations of arginine. Elevated levels of ornithine carbamoyl transferase (carbamoyl phosphate: l-ornithine carbamoyl transferase, EC 2.1.3.3) are found under circumstances leading to accumulation of argininosuccinate. An explanation based on the possibility that citrulline might impose a limited availability of arginine has been excluded. Indeed, the mutant displays a higher mycelial pool of arginine, and an increased consumption of this amino acid when it is grown with added citrulline. It is emphasized that elevated (derepressed) levels of ornithine carbamoyl transferase prevail under these conditions. © 1967.
format JOUR
author Nazario, M.
author_facet Nazario, M.
author_sort Nazario, M.
title The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
title_short The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
title_full The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
title_fullStr The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
title_full_unstemmed The accumulation of argininosuccinate in Neurospora crassa. I. Elevated ornithine carbamoyl transferase with high concentrations of arginine
title_sort accumulation of argininosuccinate in neurospora crassa. i. elevated ornithine carbamoyl transferase with high concentrations of arginine
url http://hdl.handle.net/20.500.12110/paper_00052787_v145_n1_p138_Nazario
work_keys_str_mv AT nazariom theaccumulationofargininosuccinateinneurosporacrassaielevatedornithinecarbamoyltransferasewithhighconcentrationsofarginine
AT nazariom accumulationofargininosuccinateinneurosporacrassaielevatedornithinecarbamoyltransferasewithhighconcentrationsofarginine
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