Prostaglandin E release by rat medial basal hypothalamus in vitro. Inhibition by melatonin at submicromolar concentrations

Melatonin depressed PGE release by rat medial basal hypothalamus (MBH) in vitro at concentrations 10−8 M or greater. The two-fold increase in PGE release induced by adding 10−4 M norepinephrine to MBH explants was also impaired by melatonin at micromolar or greater concentrations. These data support...

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Detalles Bibliográficos
Autores principales: Cardinali, D.P., Ritta, M.N., Fuentes, A.M., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
Medial basal hypothalamus
Melatonin
Prostaglandins
melatonin
prostaglandin E
animal
article
drug effect
hypothalamus
in vitro study
male
metabolism
rat
Animals
Hypothalamus
Hypothalamus, Middle
Male
Prostaglandins E
Rats
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v67_n1_p151_Cardinali
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Melatonin depressed PGE release by rat medial basal hypothalamus (MBH) in vitro at concentrations 10−8 M or greater. The two-fold increase in PGE release induced by adding 10−4 M norepinephrine to MBH explants was also impaired by melatonin at micromolar or greater concentrations. These data support the view that melatonin is a physiological inhibitor of PG synthesis in MBH. © 1980, All rights reserved.

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