Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes
A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the t...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00144754_v39_n6_p617_Castillo |
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todo:paper_00144754_v39_n6_p617_Castillo2023-10-03T14:12:29Z Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes Castillo, M.B. Gonzalez, M.D. Burton, G. Lantos, C.P. Roldán, A. 11beta hydroxypregna 1,4 diene 3,20 dione 11beta hydroxyprogesterone 17 deoxyprednisolone c 21 steroid corticosterone cortisone glucocorticoid hydrocortisone prednisolone radioisotope unclassified drug uridine h 3 article cytolysis dose response drug efficacy drug response in vitro study nonhuman rat RNA synthesis thymocyte thymus Animals Female Glucocorticoids Hydroxyprogesterones Male Rats Rats, Inbred Strains RNA T-Lymphocytes Thymus Gland Uridine A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions. © 1983 Birkhäuser Verlag. Fil:Castillo, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gonzalez, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144754_v39_n6_p617_Castillo |
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Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
11beta hydroxypregna 1,4 diene 3,20 dione 11beta hydroxyprogesterone 17 deoxyprednisolone c 21 steroid corticosterone cortisone glucocorticoid hydrocortisone prednisolone radioisotope unclassified drug uridine h 3 article cytolysis dose response drug efficacy drug response in vitro study nonhuman rat RNA synthesis thymocyte thymus Animals Female Glucocorticoids Hydroxyprogesterones Male Rats Rats, Inbred Strains RNA T-Lymphocytes Thymus Gland Uridine |
| spellingShingle |
11beta hydroxypregna 1,4 diene 3,20 dione 11beta hydroxyprogesterone 17 deoxyprednisolone c 21 steroid corticosterone cortisone glucocorticoid hydrocortisone prednisolone radioisotope unclassified drug uridine h 3 article cytolysis dose response drug efficacy drug response in vitro study nonhuman rat RNA synthesis thymocyte thymus Animals Female Glucocorticoids Hydroxyprogesterones Male Rats Rats, Inbred Strains RNA T-Lymphocytes Thymus Gland Uridine Castillo, M.B. Gonzalez, M.D. Burton, G. Lantos, C.P. Roldán, A. Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| topic_facet |
11beta hydroxypregna 1,4 diene 3,20 dione 11beta hydroxyprogesterone 17 deoxyprednisolone c 21 steroid corticosterone cortisone glucocorticoid hydrocortisone prednisolone radioisotope unclassified drug uridine h 3 article cytolysis dose response drug efficacy drug response in vitro study nonhuman rat RNA synthesis thymocyte thymus Animals Female Glucocorticoids Hydroxyprogesterones Male Rats Rats, Inbred Strains RNA T-Lymphocytes Thymus Gland Uridine |
| description |
A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions. © 1983 Birkhäuser Verlag. |
| format |
JOUR |
| author |
Castillo, M.B. Gonzalez, M.D. Burton, G. Lantos, C.P. Roldán, A. |
| author_facet |
Castillo, M.B. Gonzalez, M.D. Burton, G. Lantos, C.P. Roldán, A. |
| author_sort |
Castillo, M.B. |
| title |
Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| title_short |
Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| title_full |
Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| title_fullStr |
Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| title_full_unstemmed |
Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes |
| title_sort |
dissociation of glucocorticoid effects of c-21 steroids at high concentrations in thymocytes |
| url |
http://hdl.handle.net/20.500.12110/paper_00144754_v39_n6_p617_Castillo |
| work_keys_str_mv |
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| _version_ |
1807322269982130176 |