Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes

A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the t...

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Detalles Bibliográficos
Autores principales: Castillo, M.B., Gonzalez, M.D., Burton, G., Lantos, C.P., Roldán, A.
Formato: JOUR
Materias:
11beta hydroxypregna 1,4 diene 3,20 dione
11beta hydroxyprogesterone
17 deoxyprednisolone
c 21 steroid
corticosterone
cortisone
glucocorticoid
hydrocortisone
prednisolone
radioisotope
unclassified drug
uridine h 3
article
cytolysis
dose response
drug efficacy
drug response
in vitro study
nonhuman
rat
RNA synthesis
thymocyte
thymus
Animals
Female
Glucocorticoids
Hydroxyprogesterones
Male
Rats
Rats, Inbred Strains
RNA
T-Lymphocytes
Thymus Gland
Uridine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v39_n6_p617_Castillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions. © 1983 Birkhäuser Verlag.

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