Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue

Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was...

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Autores principales: Cremaschi, G.A., Sterin-Borda, L.
Formato: JOUR
Materias:
Adrenergic receptor, α-
Alloantibody
Histocompatibility antigen
Muscarinic cholinergic receptor
Phosphoinositide turnover
Phospholipase C
adrenergic receptor
alloantibody
muscarinic receptor
phosphatidylinositide
phospholipase c
radioisotope
animal cell
histocompatibility
mouse
nonhuman
priority journal
Animal
Heart Atrium
Histocompatibility Antigens Class I
Hydrolysis
Immunoglobulin G
In Vitro
Isoantibodies
Mice
Mice, Inbred C3H
Myocardium
Phosphatidylinositols
Receptors, Adrenergic, alpha
Receptors, Cholinergic
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00145793_v249_n2_p302_Cremaschi
record_format dspace
spelling todo:paper_00145793_v249_n2_p302_Cremaschi2023-10-03T14:12:58Z Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue Cremaschi, G.A. Sterin-Borda, L. Adrenergic receptor, α- Alloantibody Histocompatibility antigen Muscarinic cholinergic receptor Phosphoinositide turnover Phospholipase C adrenergic receptor alloantibody muscarinic receptor phosphatidylinositide phospholipase c radioisotope animal cell histocompatibility mouse nonhuman priority journal Animal Heart Atrium Histocompatibility Antigens Class I Hydrolysis Immunoglobulin G In Vitro Isoantibodies Mice Mice, Inbred C3H Myocardium Phosphatidylinositols Receptors, Adrenergic, alpha Receptors, Cholinergic Support, Non-U.S. Gov't Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was measured. Anti-class I, but not anti-class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α-adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C-mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α-adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone-receptor interactions is discussed. © 1989. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Adrenergic receptor, α-
Alloantibody
Histocompatibility antigen
Muscarinic cholinergic receptor
Phosphoinositide turnover
Phospholipase C
adrenergic receptor
alloantibody
muscarinic receptor
phosphatidylinositide
phospholipase c
radioisotope
animal cell
histocompatibility
mouse
nonhuman
priority journal
Animal
Heart Atrium
Histocompatibility Antigens Class I
Hydrolysis
Immunoglobulin G
In Vitro
Isoantibodies
Mice
Mice, Inbred C3H
Myocardium
Phosphatidylinositols
Receptors, Adrenergic, alpha
Receptors, Cholinergic
Support, Non-U.S. Gov't
spellingShingle Adrenergic receptor, α-
Alloantibody
Histocompatibility antigen
Muscarinic cholinergic receptor
Phosphoinositide turnover
Phospholipase C
adrenergic receptor
alloantibody
muscarinic receptor
phosphatidylinositide
phospholipase c
radioisotope
animal cell
histocompatibility
mouse
nonhuman
priority journal
Animal
Heart Atrium
Histocompatibility Antigens Class I
Hydrolysis
Immunoglobulin G
In Vitro
Isoantibodies
Mice
Mice, Inbred C3H
Myocardium
Phosphatidylinositols
Receptors, Adrenergic, alpha
Receptors, Cholinergic
Support, Non-U.S. Gov't
Cremaschi, G.A.
Sterin-Borda, L.
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
topic_facet Adrenergic receptor, α-
Alloantibody
Histocompatibility antigen
Muscarinic cholinergic receptor
Phosphoinositide turnover
Phospholipase C
adrenergic receptor
alloantibody
muscarinic receptor
phosphatidylinositide
phospholipase c
radioisotope
animal cell
histocompatibility
mouse
nonhuman
priority journal
Animal
Heart Atrium
Histocompatibility Antigens Class I
Hydrolysis
Immunoglobulin G
In Vitro
Isoantibodies
Mice
Mice, Inbred C3H
Myocardium
Phosphatidylinositols
Receptors, Adrenergic, alpha
Receptors, Cholinergic
Support, Non-U.S. Gov't
description Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was measured. Anti-class I, but not anti-class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α-adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C-mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α-adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone-receptor interactions is discussed. © 1989.
format JOUR
author Cremaschi, G.A.
Sterin-Borda, L.
author_facet Cremaschi, G.A.
Sterin-Borda, L.
author_sort Cremaschi, G.A.
title Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
title_short Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
title_full Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
title_fullStr Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
title_full_unstemmed Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
title_sort stimulation of phosphoinositide hydrolysis via class i antigen-specific recognition in murine cardiac tissue
url http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi
work_keys_str_mv AT cremaschiga stimulationofphosphoinositidehydrolysisviaclassiantigenspecificrecognitioninmurinecardiactissue
AT sterinbordal stimulationofphosphoinositidehydrolysisviaclassiantigenspecificrecognitioninmurinecardiactissue
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