Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation
The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the an...
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| Formato: | JOUR |
| Lenguaje: | English |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00207454_v119_n8_p1210_Trujillo |
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todo:paper_00207454_v119_n8_p1210_Trujillo2023-10-03T14:18:32Z Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation Trujillo, V. Masseroni, M.L. Levin, G. Surez, M.M. Anxiety Catecholamines Early maternal separation Plus maze Tianeptine Variable chronic stress adrenalin noradrenalin tianeptine adrenalin blood level animal experiment anxiety article catecholamine blood level chronic stress controlled study high performance liquid chromatography low drug dose male maternal deprivation maze test nonhuman noradrenalin blood level rat Adrenal Cortex Hormones Adrenal Medulla Animals Animals, Newborn Antidepressive Agents, Tricyclic Anxiety Anxiety, Separation Behavior, Animal Catecholamines Chronic Disease Female Male Maternal Deprivation Rats Rats, Wistar Stress, Psychological Thiazepines The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index. JOUR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00207454_v119_n8_p1210_Trujillo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
English |
| orig_language_str_mv |
English |
| topic |
Anxiety Catecholamines Early maternal separation Plus maze Tianeptine Variable chronic stress adrenalin noradrenalin tianeptine adrenalin blood level animal experiment anxiety article catecholamine blood level chronic stress controlled study high performance liquid chromatography low drug dose male maternal deprivation maze test nonhuman noradrenalin blood level rat Adrenal Cortex Hormones Adrenal Medulla Animals Animals, Newborn Antidepressive Agents, Tricyclic Anxiety Anxiety, Separation Behavior, Animal Catecholamines Chronic Disease Female Male Maternal Deprivation Rats Rats, Wistar Stress, Psychological Thiazepines |
| spellingShingle |
Anxiety Catecholamines Early maternal separation Plus maze Tianeptine Variable chronic stress adrenalin noradrenalin tianeptine adrenalin blood level animal experiment anxiety article catecholamine blood level chronic stress controlled study high performance liquid chromatography low drug dose male maternal deprivation maze test nonhuman noradrenalin blood level rat Adrenal Cortex Hormones Adrenal Medulla Animals Animals, Newborn Antidepressive Agents, Tricyclic Anxiety Anxiety, Separation Behavior, Animal Catecholamines Chronic Disease Female Male Maternal Deprivation Rats Rats, Wistar Stress, Psychological Thiazepines Trujillo, V. Masseroni, M.L. Levin, G. Surez, M.M. Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| topic_facet |
Anxiety Catecholamines Early maternal separation Plus maze Tianeptine Variable chronic stress adrenalin noradrenalin tianeptine adrenalin blood level animal experiment anxiety article catecholamine blood level chronic stress controlled study high performance liquid chromatography low drug dose male maternal deprivation maze test nonhuman noradrenalin blood level rat Adrenal Cortex Hormones Adrenal Medulla Animals Animals, Newborn Antidepressive Agents, Tricyclic Anxiety Anxiety, Separation Behavior, Animal Catecholamines Chronic Disease Female Male Maternal Deprivation Rats Rats, Wistar Stress, Psychological Thiazepines |
| description |
The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index. |
| format |
JOUR |
| author |
Trujillo, V. Masseroni, M.L. Levin, G. Surez, M.M. |
| author_facet |
Trujillo, V. Masseroni, M.L. Levin, G. Surez, M.M. |
| author_sort |
Trujillo, V. |
| title |
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| title_short |
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| title_full |
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| title_fullStr |
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| title_full_unstemmed |
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| title_sort |
tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation |
| url |
http://hdl.handle.net/20.500.12110/paper_00207454_v119_n8_p1210_Trujillo |
| work_keys_str_mv |
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| _version_ |
1807315320438784000 |