Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses

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Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that...

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Autores principales: Perez Di Giorgio, J., Soto, G., Alleva, K., Jozefkowicz, C., Amodeo, G., Muschietti, J.P., Ayub, N.D.
Formato: INPR
Lenguaje:English
Materias:
Aquaporin
Evolution
Function
Integration
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00222631_v_n_p1_PerezDiGiorgio
record_format dspace
spelling todo:paper_00222631_v_n_p1_PerezDiGiorgio2023-10-03T14:30:18Z Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses Perez Di Giorgio, J. Soto, G. Alleva, K. Jozefkowicz, C. Amodeo, G. Muschietti, J.P. Ayub, N.D. Aquaporin Evolution Function Integration Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. © 2013 Springer Science+Business Media New York. Fil:Soto, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muschietti, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ayub, N.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic Aquaporin
Evolution
Function
Integration
spellingShingle Aquaporin
Evolution
Function
Integration
Perez Di Giorgio, J.
Soto, G.
Alleva, K.
Jozefkowicz, C.
Amodeo, G.
Muschietti, J.P.
Ayub, N.D.
Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
topic_facet Aquaporin
Evolution
Function
Integration
description Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. © 2013 Springer Science+Business Media New York.
format INPR
author Perez Di Giorgio, J.
Soto, G.
Alleva, K.
Jozefkowicz, C.
Amodeo, G.
Muschietti, J.P.
Ayub, N.D.
author_facet Perez Di Giorgio, J.
Soto, G.
Alleva, K.
Jozefkowicz, C.
Amodeo, G.
Muschietti, J.P.
Ayub, N.D.
author_sort Perez Di Giorgio, J.
title Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_short Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_full Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_fullStr Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_full_unstemmed Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_sort prediction of aquaporin function by integrating evolutionary and functional analyses
url http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
work_keys_str_mv AT perezdigiorgioj predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT sotog predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT allevak predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT jozefkowiczc predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT amodeog predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
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AT ayubnd predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
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