The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells
In neuroendocrine cells, such as adrenal chromaffin cells, the exocytosis of hormone-filled vesicles is triggered by a localized Ca2+ increase that develops after the activation of voltage-dependent Ca2+ channels. To reach the fusion competent state, vesicles have to go through a series of maturatio...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00223042_v116_n2_p155_Alvarez |
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todo:paper_00223042_v116_n2_p155_Alvarez2023-10-03T14:30:48Z The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells Álvarez, Y.D. Marengo, F.D. chromaffin cells exocytosis P/Q channels voltage-dependent Ca2+ channels calcium channel calcium ion cytoskeleton protein action potential cell vacuole chromaffin cell depolarization exocytosis molecular docking molecular interaction neurosecretory cell nonhuman priority journal review stimulus response synapse vesicle Animals Calcium Channels Chromaffin Cells Exocytosis Humans Neuroendocrine Cells Synaptic Vesicles Time Factors In neuroendocrine cells, such as adrenal chromaffin cells, the exocytosis of hormone-filled vesicles is triggered by a localized Ca2+ increase that develops after the activation of voltage-dependent Ca2+ channels. To reach the fusion competent state, vesicles have to go through a series of maturation steps that involve the detachment from cytoskeletal proteins, docking and priming. However, the fusion readiness of vesicles will also depend on their proximity to the calcium source. The immediately releasable pool is a small group of ready-to-fuse vesicles, whose fusion is tightly coupled to Ca2+ entry through channels. Recent work indicates that such coupling is not produced by a random distribution between vesicles and channels, but would be the result of a specific interaction of immediately releasable vesicles with particular Ca2+ channel subtypes. The immediately releasable pool is able to sustain, with high efficiency, the secretion triggered by the small and localized Ca2+ gradients produced by brief depolarizations at low frequencies, like action potentials at basal conditions in adrenal chromaffin cells. © 2010 International Society for Neurochemistry. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223042_v116_n2_p155_Alvarez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
chromaffin cells exocytosis P/Q channels voltage-dependent Ca2+ channels calcium channel calcium ion cytoskeleton protein action potential cell vacuole chromaffin cell depolarization exocytosis molecular docking molecular interaction neurosecretory cell nonhuman priority journal review stimulus response synapse vesicle Animals Calcium Channels Chromaffin Cells Exocytosis Humans Neuroendocrine Cells Synaptic Vesicles Time Factors |
| spellingShingle |
chromaffin cells exocytosis P/Q channels voltage-dependent Ca2+ channels calcium channel calcium ion cytoskeleton protein action potential cell vacuole chromaffin cell depolarization exocytosis molecular docking molecular interaction neurosecretory cell nonhuman priority journal review stimulus response synapse vesicle Animals Calcium Channels Chromaffin Cells Exocytosis Humans Neuroendocrine Cells Synaptic Vesicles Time Factors Álvarez, Y.D. Marengo, F.D. The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| topic_facet |
chromaffin cells exocytosis P/Q channels voltage-dependent Ca2+ channels calcium channel calcium ion cytoskeleton protein action potential cell vacuole chromaffin cell depolarization exocytosis molecular docking molecular interaction neurosecretory cell nonhuman priority journal review stimulus response synapse vesicle Animals Calcium Channels Chromaffin Cells Exocytosis Humans Neuroendocrine Cells Synaptic Vesicles Time Factors |
| description |
In neuroendocrine cells, such as adrenal chromaffin cells, the exocytosis of hormone-filled vesicles is triggered by a localized Ca2+ increase that develops after the activation of voltage-dependent Ca2+ channels. To reach the fusion competent state, vesicles have to go through a series of maturation steps that involve the detachment from cytoskeletal proteins, docking and priming. However, the fusion readiness of vesicles will also depend on their proximity to the calcium source. The immediately releasable pool is a small group of ready-to-fuse vesicles, whose fusion is tightly coupled to Ca2+ entry through channels. Recent work indicates that such coupling is not produced by a random distribution between vesicles and channels, but would be the result of a specific interaction of immediately releasable vesicles with particular Ca2+ channel subtypes. The immediately releasable pool is able to sustain, with high efficiency, the secretion triggered by the small and localized Ca2+ gradients produced by brief depolarizations at low frequencies, like action potentials at basal conditions in adrenal chromaffin cells. © 2010 International Society for Neurochemistry. |
| format |
JOUR |
| author |
Álvarez, Y.D. Marengo, F.D. |
| author_facet |
Álvarez, Y.D. Marengo, F.D. |
| author_sort |
Álvarez, Y.D. |
| title |
The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| title_short |
The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| title_full |
The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| title_fullStr |
The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| title_full_unstemmed |
The immediately releasable vesicle pool: Highly coupled secretion in chromaffin and other neuroendocrine cells |
| title_sort |
immediately releasable vesicle pool: highly coupled secretion in chromaffin and other neuroendocrine cells |
| url |
http://hdl.handle.net/20.500.12110/paper_00223042_v116_n2_p155_Alvarez |
| work_keys_str_mv |
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