Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineraloco...
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todo:paper_00223042_v122_n1_p4_Galigniana2023-10-03T14:30:49Z Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 Galigniana, N.M. Ballmer, L.T. Toneatto, J. Erlejman, A.G. Lagadari, M. Galigniana, M.D. depression glucocorticoid receptor Hsp90 Hypothalamic- Pituitary-Adrenal axis immunophilin tetratricopeptide repeat domain chaperone fk 506 binding protein fk 506 binding protein 51 glucocorticoid glucocorticoid receptor heat shock protein 90 immunophilin mineralocorticoid receptor peptidylprolyl isomerase steroid receptor unclassified drug anxiety disorder Cushing disease depression disease association disease course drug resistance genetic association genetic variability hormone response human Human immunodeficiency virus infection hypothalamus hypophysis adrenal system immune response mental stress mood disorder nonhuman posttraumatic stress disorder priority journal protein binding protein defect protein domain protein expression protein function protein polymorphism protein structure protein targeting regulatory mechanism review risk factor signal transduction stress Animals Anxiety Disorders Glucocorticoids Humans Mood Disorders Peptidylprolyl Isomerase Receptors, Steroid Stress Disorders, Post-Traumatic Tacrolimus Binding Proteins Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry. Fil:Lagadari, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223042_v122_n1_p4_Galigniana |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
depression glucocorticoid receptor Hsp90 Hypothalamic- Pituitary-Adrenal axis immunophilin tetratricopeptide repeat domain chaperone fk 506 binding protein fk 506 binding protein 51 glucocorticoid glucocorticoid receptor heat shock protein 90 immunophilin mineralocorticoid receptor peptidylprolyl isomerase steroid receptor unclassified drug anxiety disorder Cushing disease depression disease association disease course drug resistance genetic association genetic variability hormone response human Human immunodeficiency virus infection hypothalamus hypophysis adrenal system immune response mental stress mood disorder nonhuman posttraumatic stress disorder priority journal protein binding protein defect protein domain protein expression protein function protein polymorphism protein structure protein targeting regulatory mechanism review risk factor signal transduction stress Animals Anxiety Disorders Glucocorticoids Humans Mood Disorders Peptidylprolyl Isomerase Receptors, Steroid Stress Disorders, Post-Traumatic Tacrolimus Binding Proteins |
| spellingShingle |
depression glucocorticoid receptor Hsp90 Hypothalamic- Pituitary-Adrenal axis immunophilin tetratricopeptide repeat domain chaperone fk 506 binding protein fk 506 binding protein 51 glucocorticoid glucocorticoid receptor heat shock protein 90 immunophilin mineralocorticoid receptor peptidylprolyl isomerase steroid receptor unclassified drug anxiety disorder Cushing disease depression disease association disease course drug resistance genetic association genetic variability hormone response human Human immunodeficiency virus infection hypothalamus hypophysis adrenal system immune response mental stress mood disorder nonhuman posttraumatic stress disorder priority journal protein binding protein defect protein domain protein expression protein function protein polymorphism protein structure protein targeting regulatory mechanism review risk factor signal transduction stress Animals Anxiety Disorders Glucocorticoids Humans Mood Disorders Peptidylprolyl Isomerase Receptors, Steroid Stress Disorders, Post-Traumatic Tacrolimus Binding Proteins Galigniana, N.M. Ballmer, L.T. Toneatto, J. Erlejman, A.G. Lagadari, M. Galigniana, M.D. Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| topic_facet |
depression glucocorticoid receptor Hsp90 Hypothalamic- Pituitary-Adrenal axis immunophilin tetratricopeptide repeat domain chaperone fk 506 binding protein fk 506 binding protein 51 glucocorticoid glucocorticoid receptor heat shock protein 90 immunophilin mineralocorticoid receptor peptidylprolyl isomerase steroid receptor unclassified drug anxiety disorder Cushing disease depression disease association disease course drug resistance genetic association genetic variability hormone response human Human immunodeficiency virus infection hypothalamus hypophysis adrenal system immune response mental stress mood disorder nonhuman posttraumatic stress disorder priority journal protein binding protein defect protein domain protein expression protein function protein polymorphism protein structure protein targeting regulatory mechanism review risk factor signal transduction stress Animals Anxiety Disorders Glucocorticoids Humans Mood Disorders Peptidylprolyl Isomerase Receptors, Steroid Stress Disorders, Post-Traumatic Tacrolimus Binding Proteins |
| description |
Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry. |
| format |
JOUR |
| author |
Galigniana, N.M. Ballmer, L.T. Toneatto, J. Erlejman, A.G. Lagadari, M. Galigniana, M.D. |
| author_facet |
Galigniana, N.M. Ballmer, L.T. Toneatto, J. Erlejman, A.G. Lagadari, M. Galigniana, M.D. |
| author_sort |
Galigniana, N.M. |
| title |
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| title_short |
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| title_full |
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| title_fullStr |
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| title_full_unstemmed |
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51 |
| title_sort |
regulation of the glucocorticoid response to stress-related disorders by the hsp90-binding immunophilin fkbp51 |
| url |
http://hdl.handle.net/20.500.12110/paper_00223042_v122_n1_p4_Galigniana |
| work_keys_str_mv |
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| _version_ |
1807316753888313344 |