Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even...
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todo:paper_00223263_v58_n7_p1847_Nudelman2023-10-03T14:31:19Z Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction Nudelman, N.S. Lewkowicz, E. Furlong, J.J.P. 13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even in diluted THF solution. Lithium pentamethyleneamide also forms aggregates with piperidine while the less acidic amines do not form mixed aggregates with the corresponding lithium dialkylamide either in the solid state or in THF solution. The product composition in the carbonylation reaction of lithium dialkylamides is highly dependent on their aggregation states, and this phenomenon can be successfully used for synthetic purposes. © 1993, American Chemical Society. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223263_v58_n7_p1847_Nudelman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| description |
13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even in diluted THF solution. Lithium pentamethyleneamide also forms aggregates with piperidine while the less acidic amines do not form mixed aggregates with the corresponding lithium dialkylamide either in the solid state or in THF solution. The product composition in the carbonylation reaction of lithium dialkylamides is highly dependent on their aggregation states, and this phenomenon can be successfully used for synthetic purposes. © 1993, American Chemical Society. All rights reserved. |
| format |
JOUR |
| author |
Nudelman, N.S. Lewkowicz, E. Furlong, J.J.P. |
| spellingShingle |
Nudelman, N.S. Lewkowicz, E. Furlong, J.J.P. Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| author_facet |
Nudelman, N.S. Lewkowicz, E. Furlong, J.J.P. |
| author_sort |
Nudelman, N.S. |
| title |
Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| title_short |
Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| title_full |
Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| title_fullStr |
Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| title_full_unstemmed |
Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction |
| title_sort |
aggregation studies of lithium diahlkylamides. the role of aggregates in the carbonylation reaction |
| url |
http://hdl.handle.net/20.500.12110/paper_00223263_v58_n7_p1847_Nudelman |
| work_keys_str_mv |
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| _version_ |
1807324174409007104 |