Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism

The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the...

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Autores principales:	Pascual, J., Borda, E., Sterin-Borda, L.
Formato:	JOUR
Materias:	adenosine triphosphatase (calcium magnesium) adenosine triphosphatase (calcium) adenosine triphosphatase (potassium sodium) Adrenergic beta Agonists beta adrenergic receptor beta adrenergic receptor stimulating agent Ca(2+) Mg(2+) ATPase Ca(2+) Transporting ATPase immunoglobulin G isoprenaline Na(+) K(+) Exchanging ATPase propranolol adult animal article Chagas disease enzymology erythrocyte guinea pig human immunology male metabolism physiology sarcolemma turkey (bird) Adrenergic beta-Agonists Adult Animal Ca(2+) Mg(2+)-ATPase Ca(2+)-Transporting ATPase Chagas Disease Erythrocytes Guinea Pigs Human Immunoglobulin G Isoproterenol Male Na(+)-K(+)-Exchanging ATPase Propranolol Receptors, Adrenergic, beta Sarcolemma Support, Non-U.S. Gov't Turkeys
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00243205_v40_n4_p313_Pascual
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00243205_v40_n4_p313_Pascual2023-10-03T14:34:35Z Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism Pascual, J. Borda, E. Sterin-Borda, L. adenosine triphosphatase (calcium magnesium) adenosine triphosphatase (calcium) adenosine triphosphatase (potassium sodium) Adrenergic beta Agonists beta adrenergic receptor beta adrenergic receptor stimulating agent Ca(2+) Mg(2+) ATPase Ca(2+) Transporting ATPase immunoglobulin G isoprenaline Na(+) K(+) Exchanging ATPase propranolol adult animal article Chagas disease enzymology erythrocyte guinea pig human immunology male metabolism physiology sarcolemma turkey (bird) Adrenergic beta-Agonists Adult Animal Ca(2+) Mg(2+)-ATPase Ca(2+)-Transporting ATPase Chagas Disease Erythrocytes Guinea Pigs Human Immunoglobulin G Isoproterenol Male Na(+)-K(+)-Exchanging ATPase Propranolol Receptors, Adrenergic, beta Sarcolemma Support, Non-U.S. Gov't Turkeys The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. Isoproterenol acted similarly. These results provide information concerning to the biochemical mechanism, by which an antibody, known to activate adenylate cyclase system coupled to cardiac β adrenoceptor, produces stimulation of myocardial contractility. © 1987. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00243205_v40_n4_p313_Pascual
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adenosine triphosphatase (calcium magnesium) adenosine triphosphatase (calcium) adenosine triphosphatase (potassium sodium) Adrenergic beta Agonists beta adrenergic receptor beta adrenergic receptor stimulating agent Ca(2+) Mg(2+) ATPase Ca(2+) Transporting ATPase immunoglobulin G isoprenaline Na(+) K(+) Exchanging ATPase propranolol adult animal article Chagas disease enzymology erythrocyte guinea pig human immunology male metabolism physiology sarcolemma turkey (bird) Adrenergic beta-Agonists Adult Animal Ca(2+) Mg(2+)-ATPase Ca(2+)-Transporting ATPase Chagas Disease Erythrocytes Guinea Pigs Human Immunoglobulin G Isoproterenol Male Na(+)-K(+)-Exchanging ATPase Propranolol Receptors, Adrenergic, beta Sarcolemma Support, Non-U.S. Gov't Turkeys
spellingShingle	adenosine triphosphatase (calcium magnesium) adenosine triphosphatase (calcium) adenosine triphosphatase (potassium sodium) Adrenergic beta Agonists beta adrenergic receptor beta adrenergic receptor stimulating agent Ca(2+) Mg(2+) ATPase Ca(2+) Transporting ATPase immunoglobulin G isoprenaline Na(+) K(+) Exchanging ATPase propranolol adult animal article Chagas disease enzymology erythrocyte guinea pig human immunology male metabolism physiology sarcolemma turkey (bird) Adrenergic beta-Agonists Adult Animal Ca(2+) Mg(2+)-ATPase Ca(2+)-Transporting ATPase Chagas Disease Erythrocytes Guinea Pigs Human Immunoglobulin G Isoproterenol Male Na(+)-K(+)-Exchanging ATPase Propranolol Receptors, Adrenergic, beta Sarcolemma Support, Non-U.S. Gov't Turkeys Pascual, J. Borda, E. Sterin-Borda, L. Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
topic_facet	adenosine triphosphatase (calcium magnesium) adenosine triphosphatase (calcium) adenosine triphosphatase (potassium sodium) Adrenergic beta Agonists beta adrenergic receptor beta adrenergic receptor stimulating agent Ca(2+) Mg(2+) ATPase Ca(2+) Transporting ATPase immunoglobulin G isoprenaline Na(+) K(+) Exchanging ATPase propranolol adult animal article Chagas disease enzymology erythrocyte guinea pig human immunology male metabolism physiology sarcolemma turkey (bird) Adrenergic beta-Agonists Adult Animal Ca(2+) Mg(2+)-ATPase Ca(2+)-Transporting ATPase Chagas Disease Erythrocytes Guinea Pigs Human Immunoglobulin G Isoproterenol Male Na(+)-K(+)-Exchanging ATPase Propranolol Receptors, Adrenergic, beta Sarcolemma Support, Non-U.S. Gov't Turkeys
description	The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. Isoproterenol acted similarly. These results provide information concerning to the biochemical mechanism, by which an antibody, known to activate adenylate cyclase system coupled to cardiac β adrenoceptor, produces stimulation of myocardial contractility. © 1987.
format	JOUR
author	Pascual, J. Borda, E. Sterin-Borda, L.
author_facet	Pascual, J. Borda, E. Sterin-Borda, L.
author_sort	Pascual, J.
title	Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
title_short	Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
title_full	Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
title_fullStr	Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
title_full_unstemmed	Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
title_sort	chagasic igg modifies the activity of sarcolemmal atpases through a β adrenergic mechanism
url	http://hdl.handle.net/20.500.12110/paper_00243205_v40_n4_p313_Pascual
work_keys_str_mv	AT pascualj chagasiciggmodifiestheactivityofsarcolemmalatpasesthroughabadrenergicmechanism AT bordae chagasiciggmodifiestheactivityofsarcolemmalatpasesthroughabadrenergicmechanism AT sterinbordal chagasiciggmodifiestheactivityofsarcolemmalatpasesthroughabadrenergicmechanism
_version_	1807317549987135488

Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism

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