Cytotoxic terpenoids from Nardophyllum bryoides
The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and...
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todo:paper_00319422_v71_n11-12_p1395_Sanchez2023-10-03T14:44:30Z Cytotoxic terpenoids from Nardophyllum bryoides Sánchez, M. Mazzuca, M. Veloso, M.J. Fernández, L.R. Siless, G. Puricelli, L. Palermo, J.A. Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and ursane triterpenoids (6-11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound. © 2010 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319422_v71_n11-12_p1395_Sanchez |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes |
| spellingShingle |
Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Sánchez, M. Mazzuca, M. Veloso, M.J. Fernández, L.R. Siless, G. Puricelli, L. Palermo, J.A. Cytotoxic terpenoids from Nardophyllum bryoides |
| topic_facet |
Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes |
| description |
The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and ursane triterpenoids (6-11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound. © 2010 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Sánchez, M. Mazzuca, M. Veloso, M.J. Fernández, L.R. Siless, G. Puricelli, L. Palermo, J.A. |
| author_facet |
Sánchez, M. Mazzuca, M. Veloso, M.J. Fernández, L.R. Siless, G. Puricelli, L. Palermo, J.A. |
| author_sort |
Sánchez, M. |
| title |
Cytotoxic terpenoids from Nardophyllum bryoides |
| title_short |
Cytotoxic terpenoids from Nardophyllum bryoides |
| title_full |
Cytotoxic terpenoids from Nardophyllum bryoides |
| title_fullStr |
Cytotoxic terpenoids from Nardophyllum bryoides |
| title_full_unstemmed |
Cytotoxic terpenoids from Nardophyllum bryoides |
| title_sort |
cytotoxic terpenoids from nardophyllum bryoides |
| url |
http://hdl.handle.net/20.500.12110/paper_00319422_v71_n11-12_p1395_Sanchez |
| work_keys_str_mv |
AT sanchezm cytotoxicterpenoidsfromnardophyllumbryoides AT mazzucam cytotoxicterpenoidsfromnardophyllumbryoides AT velosomj cytotoxicterpenoidsfromnardophyllumbryoides AT fernandezlr cytotoxicterpenoidsfromnardophyllumbryoides AT silessg cytotoxicterpenoidsfromnardophyllumbryoides AT puricellil cytotoxicterpenoidsfromnardophyllumbryoides AT palermoja cytotoxicterpenoidsfromnardophyllumbryoides |
| _version_ |
1807322813043834880 |