New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated...

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Autores principales:	Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., Durán, F.J., Palermo, J.A., Simões, C.M.O., Caro, M.S.B., Schenkel, E.P.
Formato:	JOUR
Materias:	Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00320943_v77_n14_p1648_Lang
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spelling	todo:paper_00320943_v77_n14_p1648_Lang2023-10-03T14:45:07Z New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn Lang, K.L. Da Rosa Guimarães, T. Rocha MacHado, V. Zimmermann, L.A. Silva, I.T. Teixeira, M.R. Durán, F.J. Palermo, J.A. Simões, C.M.O. Caro, M.S.B. Schenkel, E.P. Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata
spellingShingle	Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata Lang, K.L. Da Rosa Guimarães, T. Rocha MacHado, V. Zimmermann, L.A. Silva, I.T. Teixeira, M.R. Durán, F.J. Palermo, J.A. Simões, C.M.O. Caro, M.S.B. Schenkel, E.P. New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
topic_facet	Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata
description	Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·.
format	JOUR
author	Lang, K.L. Da Rosa Guimarães, T. Rocha MacHado, V. Zimmermann, L.A. Silva, I.T. Teixeira, M.R. Durán, F.J. Palermo, J.A. Simões, C.M.O. Caro, M.S.B. Schenkel, E.P.
author_facet	Lang, K.L. Da Rosa Guimarães, T. Rocha MacHado, V. Zimmermann, L.A. Silva, I.T. Teixeira, M.R. Durán, F.J. Palermo, J.A. Simões, C.M.O. Caro, M.S.B. Schenkel, E.P.
author_sort	Lang, K.L.
title	New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
title_short	New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
title_full	New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
title_fullStr	New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
title_full_unstemmed	New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
title_sort	new cytotoxic cucurbitacins from wilbrandia ebracteata cogn
url	http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang
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New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

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