New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lang, K.L., Da Rosa Guimarães, T., Rocha MacHado, V., Zimmermann, L.A., Silva, I.T., Teixeira, M.R., Durán, F.J., Palermo, J.A., Simões, C.M.O., Caro, M.S.B., Schenkel, E.P.
Formato: JOUR
Materias:
Cucurbitaceae
cucurbitacins
cytotoxicity
Wilbrandia ebracteata
2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione
2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione
cucurbitacin
cytotoxic agent
unclassified drug
Wilbrandia ebracteata extract
article
chemical structure
cucumber
drug isolation
human
human cell
in vitro study
mass spectrometry
nuclear magnetic resonance
plant root
Brazil
Cell Line, Tumor
Cell Survival
Chromatography, High Pressure Liquid
Cucurbitacins
Humans
Medicine, Traditional
Molecular Structure
Plant Extracts
Plant Roots
Plants, Medicinal
Spectrometry, Mass, Electrospray Ionization
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·.

Ejemplares similares