Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer
A linear polyamidoamine oligomer was obtained by polymerization of ethyl acrylate and N-methyl-1,3-diaminopropane, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymeriz...
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Autores principales: | , , , , |
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Formato: | JOUR |
Materias: | |
Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00323861_v51_n14_p2998_Monsalve |
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Sumario: | A linear polyamidoamine oligomer was obtained by polymerization of ethyl acrylate and N-methyl-1,3-diaminopropane, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymerization reaction or Michael adducts formation. The polymeric material, characterized by FTIR, 1H and 13C NMR and UV-MALDI-TOF-MS, shows low molecular weight and high monodispersity. The activity showed by C. antarctica lipase in the polymerization reaction is highly selective and allows to obtain a product with potential biomedical applications in mild condition reactions and low environmental impact. © 2010 Elsevier Ltd. |
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