The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large fam...
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00368075_v309_n5733_p409_ElSayed |
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todo:paper_00368075_v309_n5733_p409_ElSayed2023-10-03T14:47:50Z The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease El-Sayed, N.M. Myler, P.J. Bartholomeu, D.C. Nilsson, D. Aggarwal, G. Tran, A.-N. Ghedin, E. Worthey, E.A. Delcher, A.L. Blandin, G. Westenberger, S.J. Caler, E. Cerqueira, G.C. Branche, C. Haas, B. Anupama, A. Arner, E. Åslund, L. Attipoe, P. Bontempi, E. Bringaud, F. Burton, P. Cadag, E. Campbell, D.A. Carrington, M. Crabtree, J. Darban, H. Da Silveira, J.F. De Jong, P. Edwards, K. Englund, P.T. Fazelina, G. Feldblyum, T. Ferella, M. Frasch, A.C. Gull, K. Horn, D. Hou, L. Huang, Y. Kindlund, E. Klingbeil, M. Kluge, S. Koo, H. Lacerda, D. Levin, M.J. Lorenzi, H. Louie, T. Machado, C.R. McCulloch, R. McKenna, A. Mizuno, Y. Mottram, J.C. Nelson, S. Ochaya, S. Osoegawa, K. Pai, G. Parsons, M. Pentony, M. Pettersson, U. Pop, M. Ramirez, J.L. Rinta, J. Robertson, L. Salzberg, S.L. Sanchez, D.O. Seyler, A. Sharma, R. Shetty, J. Simpson, A.J. Sisk, E. Tammi, M.T. Tarleton, R. Teixeira, S. Van Aken, S. Vogt, C. Ward, P.N. Wickstead, B. Wortman, J. White, O. Fraser, C.M. Stuart, K.D. Andersson, B. Diseases DNA Genes Proteins Chagas diseases Surface molecules Trypanosoma cruzi Protozoa gene product membrane protein mitochondrial DNA mucin phosphatase protein kinase protozoal protein sialidase genome allele article Chagas disease diploidy DNA repair DNA replication eukaryote gene sequence genome analysis Leishmania major molecular size multigene family nonhuman priority journal retroposon signal transduction Trypanosoma brucei Trypanosoma cruzi Animals Chagas Disease DNA Repair DNA Replication DNA, Mitochondrial DNA, Protozoan Genes, Protozoan Genome, Protozoan Humans Meiosis Membrane Proteins Multigene Family Protozoan Proteins Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroelements Sequence Analysis, DNA Signal Transduction Telomere Trypanocidal Agents Trypanosoma cruzi Eukaryota Leishmania major Protozoa Trypanosoma cruzi Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00368075_v309_n5733_p409_ElSayed |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Diseases DNA Genes Proteins Chagas diseases Surface molecules Trypanosoma cruzi Protozoa gene product membrane protein mitochondrial DNA mucin phosphatase protein kinase protozoal protein sialidase genome allele article Chagas disease diploidy DNA repair DNA replication eukaryote gene sequence genome analysis Leishmania major molecular size multigene family nonhuman priority journal retroposon signal transduction Trypanosoma brucei Trypanosoma cruzi Animals Chagas Disease DNA Repair DNA Replication DNA, Mitochondrial DNA, Protozoan Genes, Protozoan Genome, Protozoan Humans Meiosis Membrane Proteins Multigene Family Protozoan Proteins Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroelements Sequence Analysis, DNA Signal Transduction Telomere Trypanocidal Agents Trypanosoma cruzi Eukaryota Leishmania major Protozoa Trypanosoma cruzi |
| spellingShingle |
Diseases DNA Genes Proteins Chagas diseases Surface molecules Trypanosoma cruzi Protozoa gene product membrane protein mitochondrial DNA mucin phosphatase protein kinase protozoal protein sialidase genome allele article Chagas disease diploidy DNA repair DNA replication eukaryote gene sequence genome analysis Leishmania major molecular size multigene family nonhuman priority journal retroposon signal transduction Trypanosoma brucei Trypanosoma cruzi Animals Chagas Disease DNA Repair DNA Replication DNA, Mitochondrial DNA, Protozoan Genes, Protozoan Genome, Protozoan Humans Meiosis Membrane Proteins Multigene Family Protozoan Proteins Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroelements Sequence Analysis, DNA Signal Transduction Telomere Trypanocidal Agents Trypanosoma cruzi Eukaryota Leishmania major Protozoa Trypanosoma cruzi El-Sayed, N.M. Myler, P.J. Bartholomeu, D.C. Nilsson, D. Aggarwal, G. Tran, A.-N. Ghedin, E. Worthey, E.A. Delcher, A.L. Blandin, G. Westenberger, S.J. Caler, E. Cerqueira, G.C. Branche, C. Haas, B. Anupama, A. Arner, E. Åslund, L. Attipoe, P. Bontempi, E. Bringaud, F. Burton, P. Cadag, E. Campbell, D.A. Carrington, M. Crabtree, J. Darban, H. Da Silveira, J.F. De Jong, P. Edwards, K. Englund, P.T. Fazelina, G. Feldblyum, T. Ferella, M. Frasch, A.C. Gull, K. Horn, D. Hou, L. Huang, Y. Kindlund, E. Klingbeil, M. Kluge, S. Koo, H. Lacerda, D. Levin, M.J. Lorenzi, H. Louie, T. Machado, C.R. McCulloch, R. McKenna, A. Mizuno, Y. Mottram, J.C. Nelson, S. Ochaya, S. Osoegawa, K. Pai, G. Parsons, M. Pentony, M. Pettersson, U. Pop, M. Ramirez, J.L. Rinta, J. Robertson, L. Salzberg, S.L. Sanchez, D.O. Seyler, A. Sharma, R. Shetty, J. Simpson, A.J. Sisk, E. Tammi, M.T. Tarleton, R. Teixeira, S. Van Aken, S. Vogt, C. Ward, P.N. Wickstead, B. Wortman, J. White, O. Fraser, C.M. Stuart, K.D. Andersson, B. The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| topic_facet |
Diseases DNA Genes Proteins Chagas diseases Surface molecules Trypanosoma cruzi Protozoa gene product membrane protein mitochondrial DNA mucin phosphatase protein kinase protozoal protein sialidase genome allele article Chagas disease diploidy DNA repair DNA replication eukaryote gene sequence genome analysis Leishmania major molecular size multigene family nonhuman priority journal retroposon signal transduction Trypanosoma brucei Trypanosoma cruzi Animals Chagas Disease DNA Repair DNA Replication DNA, Mitochondrial DNA, Protozoan Genes, Protozoan Genome, Protozoan Humans Meiosis Membrane Proteins Multigene Family Protozoan Proteins Recombination, Genetic Repetitive Sequences, Nucleic Acid Retroelements Sequence Analysis, DNA Signal Transduction Telomere Trypanocidal Agents Trypanosoma cruzi Eukaryota Leishmania major Protozoa Trypanosoma cruzi |
| description |
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. |
| format |
JOUR |
| author |
El-Sayed, N.M. Myler, P.J. Bartholomeu, D.C. Nilsson, D. Aggarwal, G. Tran, A.-N. Ghedin, E. Worthey, E.A. Delcher, A.L. Blandin, G. Westenberger, S.J. Caler, E. Cerqueira, G.C. Branche, C. Haas, B. Anupama, A. Arner, E. Åslund, L. Attipoe, P. Bontempi, E. Bringaud, F. Burton, P. Cadag, E. Campbell, D.A. Carrington, M. Crabtree, J. Darban, H. Da Silveira, J.F. De Jong, P. Edwards, K. Englund, P.T. Fazelina, G. Feldblyum, T. Ferella, M. Frasch, A.C. Gull, K. Horn, D. Hou, L. Huang, Y. Kindlund, E. Klingbeil, M. Kluge, S. Koo, H. Lacerda, D. Levin, M.J. Lorenzi, H. Louie, T. Machado, C.R. McCulloch, R. McKenna, A. Mizuno, Y. Mottram, J.C. Nelson, S. Ochaya, S. Osoegawa, K. Pai, G. Parsons, M. Pentony, M. Pettersson, U. Pop, M. Ramirez, J.L. Rinta, J. Robertson, L. Salzberg, S.L. Sanchez, D.O. Seyler, A. Sharma, R. Shetty, J. Simpson, A.J. Sisk, E. Tammi, M.T. Tarleton, R. Teixeira, S. Van Aken, S. Vogt, C. Ward, P.N. Wickstead, B. Wortman, J. White, O. Fraser, C.M. Stuart, K.D. Andersson, B. |
| author_facet |
El-Sayed, N.M. Myler, P.J. Bartholomeu, D.C. Nilsson, D. Aggarwal, G. Tran, A.-N. Ghedin, E. Worthey, E.A. Delcher, A.L. Blandin, G. Westenberger, S.J. Caler, E. Cerqueira, G.C. Branche, C. Haas, B. Anupama, A. Arner, E. Åslund, L. Attipoe, P. Bontempi, E. Bringaud, F. Burton, P. Cadag, E. Campbell, D.A. Carrington, M. Crabtree, J. Darban, H. Da Silveira, J.F. De Jong, P. Edwards, K. Englund, P.T. Fazelina, G. Feldblyum, T. Ferella, M. Frasch, A.C. Gull, K. Horn, D. Hou, L. Huang, Y. Kindlund, E. Klingbeil, M. Kluge, S. Koo, H. Lacerda, D. Levin, M.J. Lorenzi, H. Louie, T. Machado, C.R. McCulloch, R. McKenna, A. Mizuno, Y. Mottram, J.C. Nelson, S. Ochaya, S. Osoegawa, K. Pai, G. Parsons, M. Pentony, M. Pettersson, U. Pop, M. Ramirez, J.L. Rinta, J. Robertson, L. Salzberg, S.L. Sanchez, D.O. Seyler, A. Sharma, R. Shetty, J. Simpson, A.J. Sisk, E. Tammi, M.T. Tarleton, R. Teixeira, S. Van Aken, S. Vogt, C. Ward, P.N. Wickstead, B. Wortman, J. White, O. Fraser, C.M. Stuart, K.D. Andersson, B. |
| author_sort |
El-Sayed, N.M. |
| title |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_short |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_full |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_fullStr |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_full_unstemmed |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_sort |
genome sequence of trypanosoma cruzi, etiologic agent of chagas disease |
| url |
http://hdl.handle.net/20.500.12110/paper_00368075_v309_n5733_p409_ElSayed |
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| _version_ |
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