Patagonicoside A: A novel antifungal disulfated triterpene glycoside from the sea cucumber Psolus patagonicus

A new triterpene glycoside, patagonicoside A (1), has been isolated from the sea cucumber Psolus patagonicus and its structure has been elucidated by 1D and 2D NMR (1H-, 13C-, 1H-1H COSY, HETCOR, COLOC and NOESY spectra), FAB-MS and chemical evidence. Compound 1 is a disulfated tetrasaccharide with...

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Detalles Bibliográficos
Autores principales: Murray, A.P., Muniaín, C., Seldes, A.M., Maier, M.S.
Formato: JOUR
Materias:
Antifungal activity
Glycosides
Holothuroidea
Psolus patagonicus
Triterpenes
antifungal agent
glycoside
patagonicoside a
triterpenic glycoside
unclassified drug
antifungal activity
article
carbon nuclear magnetic resonance
Cladosporium cucumerinum
controlled study
desulfurization
dose response
drug isolation
drug structure
echinoderm
mass spectrometry
nonhuman
priority journal
proton nuclear magnetic resonance
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00404020_v57_n47_p9563_Murray
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:A new triterpene glycoside, patagonicoside A (1), has been isolated from the sea cucumber Psolus patagonicus and its structure has been elucidated by 1D and 2D NMR (1H-, 13C-, 1H-1H COSY, HETCOR, COLOC and NOESY spectra), FAB-MS and chemical evidence. Compound 1 is a disulfated tetrasaccharide with a new aglycon moiety. Patagonicoside A (1) exhibits considerable antifungal activity against the pathogenic fungus Cladosporium cucumerinum. © 2001 Elsevier Science Ltd. All rights reserved.

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