In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions

It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects...

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Autores principales:	Chirife, J., Herszage, L., Joseph, A., Bozzini, J.P., Leardini, N., Kohn, E.S.
Formato:	JOUR
Materias:	macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00664804_v24_n3_p409_Chirife
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spelling	todo:paper_00664804_v24_n3_p409_Chirife2023-10-03T14:53:04Z In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions Chirife, J. Herszage, L. Joseph, A. Bozzini, J.P. Leardini, N. Kohn, E.S. macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects: lowering of water activity and, superimposed on this, the specific action of PEG-400 molecules on bacterial cells. Phase-contrast microscopic observations of cells placed in contact with PEG 400 revealed clumping and morphological changes of bacterial cells. The larger changes in appearances were evidenced by the species which were more rapidly killed by PEG 400. The results obtained suggested that concentrated PEG 400 solutions may have a potential value in medicine as a topical antibacterial agent. The feasibility of this application is the subject of present investigation. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus
spellingShingle	macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus Chirife, J. Herszage, L. Joseph, A. Bozzini, J.P. Leardini, N. Kohn, E.S. In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
topic_facet	macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus
description	It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects: lowering of water activity and, superimposed on this, the specific action of PEG-400 molecules on bacterial cells. Phase-contrast microscopic observations of cells placed in contact with PEG 400 revealed clumping and morphological changes of bacterial cells. The larger changes in appearances were evidenced by the species which were more rapidly killed by PEG 400. The results obtained suggested that concentrated PEG 400 solutions may have a potential value in medicine as a topical antibacterial agent. The feasibility of this application is the subject of present investigation.
format	JOUR
author	Chirife, J. Herszage, L. Joseph, A. Bozzini, J.P. Leardini, N. Kohn, E.S.
author_facet	Chirife, J. Herszage, L. Joseph, A. Bozzini, J.P. Leardini, N. Kohn, E.S.
author_sort	Chirife, J.
title	In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
title_short	In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
title_full	In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
title_fullStr	In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
title_full_unstemmed	In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
title_sort	in vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
url	http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife
work_keys_str_mv	AT chirifej invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions AT herszagel invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions AT josepha invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions AT bozzinijp invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions AT leardinin invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions AT kohnes invitroantibacterialactivityofconcentratedpolyethyleneglycol400solutions
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In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions

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