Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)

The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time...

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Autores principales: Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
phentolamine
propranolol
prostacyclin
estrus
human
human cell
in vitro study
muscle contractility
normal human
ovarian vein
peripheral vascular system
venoconstriction
Adult
Epoprostenol
Female
Humans
Muscle Contraction
Ovary
Phentolamine
Propranolol
Prostaglandins
Veins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00906980_v18_n6_p829_Borda
record_format dspace
spelling todo:paper_00906980_v18_n6_p829_Borda2023-10-03T14:54:45Z Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) Borda, E.S. Agostini, M.C. Sterin-Speziale, N. Gimeno, M.F. Gimeno, A.L. phentolamine propranolol prostacyclin estrus human human cell in vitro study muscle contractility normal human ovarian vein peripheral vascular system venoconstriction Adult Epoprostenol Female Humans Muscle Contraction Ovary Phentolamine Propranolol Prostaglandins Veins The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time progresses, dissapearing almost completely following more than two hours. PGI2 produced a biphasic influence on quiescent preparations. After the threshold is attained lower concentrations caused depression of tone whereas higher ones enhanced the basal tone and induced phasic contractile cycles. Phentolamine reduced markedly the stimulating influence of PGI2 but had no action on the inhibitory effects, whereas propranolol failed to alter either the excitatory or the depressive action. The results suggest a participation of alpha-adrenoceptive-mediated mechanisms in the stimulatory effects of PGI2. On the other hand, PGI2 may be of importance in the regulation of venous flow and the spontaneous or PGI2-induced contractions could play a role in the counter current mechanism between veins and arteries in the ovarian pedicle. © 1980. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic phentolamine
propranolol
prostacyclin
estrus
human
human cell
in vitro study
muscle contractility
normal human
ovarian vein
peripheral vascular system
venoconstriction
Adult
Epoprostenol
Female
Humans
Muscle Contraction
Ovary
Phentolamine
Propranolol
Prostaglandins
Veins
spellingShingle phentolamine
propranolol
prostacyclin
estrus
human
human cell
in vitro study
muscle contractility
normal human
ovarian vein
peripheral vascular system
venoconstriction
Adult
Epoprostenol
Female
Humans
Muscle Contraction
Ovary
Phentolamine
Propranolol
Prostaglandins
Veins
Borda, E.S.
Agostini, M.C.
Sterin-Speziale, N.
Gimeno, M.F.
Gimeno, A.L.
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
topic_facet phentolamine
propranolol
prostacyclin
estrus
human
human cell
in vitro study
muscle contractility
normal human
ovarian vein
peripheral vascular system
venoconstriction
Adult
Epoprostenol
Female
Humans
Muscle Contraction
Ovary
Phentolamine
Propranolol
Prostaglandins
Veins
description The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time progresses, dissapearing almost completely following more than two hours. PGI2 produced a biphasic influence on quiescent preparations. After the threshold is attained lower concentrations caused depression of tone whereas higher ones enhanced the basal tone and induced phasic contractile cycles. Phentolamine reduced markedly the stimulating influence of PGI2 but had no action on the inhibitory effects, whereas propranolol failed to alter either the excitatory or the depressive action. The results suggest a participation of alpha-adrenoceptive-mediated mechanisms in the stimulatory effects of PGI2. On the other hand, PGI2 may be of importance in the regulation of venous flow and the spontaneous or PGI2-induced contractions could play a role in the counter current mechanism between veins and arteries in the ovarian pedicle. © 1980.
format JOUR
author Borda, E.S.
Agostini, M.C.
Sterin-Speziale, N.
Gimeno, M.F.
Gimeno, A.L.
author_facet Borda, E.S.
Agostini, M.C.
Sterin-Speziale, N.
Gimeno, M.F.
Gimeno, A.L.
author_sort Borda, E.S.
title Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
title_short Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
title_full Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
title_fullStr Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
title_full_unstemmed Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
title_sort spontaneous contractile activity of isolated ovarian human vein. a dual influence of prostacyclin (pgi2)
url http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda
work_keys_str_mv AT bordaes spontaneouscontractileactivityofisolatedovarianhumanveinadualinfluenceofprostacyclinpgi2
AT agostinimc spontaneouscontractileactivityofisolatedovarianhumanveinadualinfluenceofprostacyclinpgi2
AT sterinspezialen spontaneouscontractileactivityofisolatedovarianhumanveinadualinfluenceofprostacyclinpgi2
AT gimenomf spontaneouscontractileactivityofisolatedovarianhumanveinadualinfluenceofprostacyclinpgi2
AT gimenoal spontaneouscontractileactivityofisolatedovarianhumanveinadualinfluenceofprostacyclinpgi2
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