Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas...

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Autores principales:	Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Medina, J.H., Viola, H.
Formato:	JOUR
Materias:	Hesperidin Mouse pαCaMKII pERK 1/2 Sedation calcium calmodulin dependent protein kinase calcium calmodulin dependent protein kinase ii alpha drug vehicle flavonoid glycoside hesperidin mitogen activated protein kinase 1 mitogen activated protein kinase 3 neohesperidin unclassified drug animal cell animal experiment animal model animal tissue article brain cortex cerebellum controlled study depression drug efficacy enzyme inactivation enzyme phosphorylation intracellular transport locomotion male mouse nonhuman priority journal sedation Animals Behavior, Animal Brain Hypnotics and Sedatives Male Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Signal Transduction Mus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00913057_v92_n2_p291_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00913057_v92_n2_p291_Martinez
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spelling	todo:paper_00913057_v92_n2_p291_Martinez2023-10-03T14:54:59Z Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice Martínez, M.C. Fernandez, S.P. Loscalzo, L.M. Wasowski, C. Paladini, A.C. Marder, M. Medina, J.H. Viola, H. Hesperidin Mouse pαCaMKII pERK 1/2 Sedation calcium calmodulin dependent protein kinase calcium calmodulin dependent protein kinase ii alpha drug vehicle flavonoid glycoside hesperidin mitogen activated protein kinase 1 mitogen activated protein kinase 3 neohesperidin unclassified drug animal cell animal experiment animal model animal tissue article brain cortex cerebellum controlled study depression drug efficacy enzyme inactivation enzyme phosphorylation intracellular transport locomotion male mouse nonhuman priority journal sedation Animals Behavior, Animal Brain Hesperidin Hypnotics and Sedatives Male Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Signal Transduction Mus The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas of the brain. The systemic administration of hesperidin produced a marked reduction in the phosphorylation state of extracellular signal-regulated kinases 1/2 (ERK 1/2), but not of Ca+2/calmodulin-dependent protein kinase II α subunit (αCaMKII), in the cerebral cortex, cerebellum and hippocampus. In contrast, neo-hesperidin did not markedly affect the activity of ERK 1/2 in both the cortex and the cerebellum. Taken together, these results demonstrated that intracellular signalling involving a selective decrease in ERK1/2 activation accompanied the depressant action of hesperidin. Even more, the low sedative action of neo-hesperidin correlates with a negligible decrease in phosphorylation state of ERK 1/2 (pERK 1/2), suggesting that low levels of pERK 1/2 in CNS could be a marker of sedative efficacy of flavonoids. © 2008 Elsevier Inc. All rights reserved. Fil:Martínez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00913057_v92_n2_p291_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Hesperidin Mouse pαCaMKII pERK 1/2 Sedation calcium calmodulin dependent protein kinase calcium calmodulin dependent protein kinase ii alpha drug vehicle flavonoid glycoside hesperidin mitogen activated protein kinase 1 mitogen activated protein kinase 3 neohesperidin unclassified drug animal cell animal experiment animal model animal tissue article brain cortex cerebellum controlled study depression drug efficacy enzyme inactivation enzyme phosphorylation intracellular transport locomotion male mouse nonhuman priority journal sedation Animals Behavior, Animal Brain Hesperidin Hypnotics and Sedatives Male Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Signal Transduction Mus
spellingShingle	Hesperidin Mouse pαCaMKII pERK 1/2 Sedation calcium calmodulin dependent protein kinase calcium calmodulin dependent protein kinase ii alpha drug vehicle flavonoid glycoside hesperidin mitogen activated protein kinase 1 mitogen activated protein kinase 3 neohesperidin unclassified drug animal cell animal experiment animal model animal tissue article brain cortex cerebellum controlled study depression drug efficacy enzyme inactivation enzyme phosphorylation intracellular transport locomotion male mouse nonhuman priority journal sedation Animals Behavior, Animal Brain Hesperidin Hypnotics and Sedatives Male Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Signal Transduction Mus Martínez, M.C. Fernandez, S.P. Loscalzo, L.M. Wasowski, C. Paladini, A.C. Marder, M. Medina, J.H. Viola, H. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
topic_facet	Hesperidin Mouse pαCaMKII pERK 1/2 Sedation calcium calmodulin dependent protein kinase calcium calmodulin dependent protein kinase ii alpha drug vehicle flavonoid glycoside hesperidin mitogen activated protein kinase 1 mitogen activated protein kinase 3 neohesperidin unclassified drug animal cell animal experiment animal model animal tissue article brain cortex cerebellum controlled study depression drug efficacy enzyme inactivation enzyme phosphorylation intracellular transport locomotion male mouse nonhuman priority journal sedation Animals Behavior, Animal Brain Hesperidin Hypnotics and Sedatives Male Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Phosphorylation Signal Transduction Mus
description	The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas of the brain. The systemic administration of hesperidin produced a marked reduction in the phosphorylation state of extracellular signal-regulated kinases 1/2 (ERK 1/2), but not of Ca+2/calmodulin-dependent protein kinase II α subunit (αCaMKII), in the cerebral cortex, cerebellum and hippocampus. In contrast, neo-hesperidin did not markedly affect the activity of ERK 1/2 in both the cortex and the cerebellum. Taken together, these results demonstrated that intracellular signalling involving a selective decrease in ERK1/2 activation accompanied the depressant action of hesperidin. Even more, the low sedative action of neo-hesperidin correlates with a negligible decrease in phosphorylation state of ERK 1/2 (pERK 1/2), suggesting that low levels of pERK 1/2 in CNS could be a marker of sedative efficacy of flavonoids. © 2008 Elsevier Inc. All rights reserved.
format	JOUR
author	Martínez, M.C. Fernandez, S.P. Loscalzo, L.M. Wasowski, C. Paladini, A.C. Marder, M. Medina, J.H. Viola, H.
author_facet	Martínez, M.C. Fernandez, S.P. Loscalzo, L.M. Wasowski, C. Paladini, A.C. Marder, M. Medina, J.H. Viola, H.
author_sort	Martínez, M.C.
title	Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
title_short	Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
title_full	Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
title_fullStr	Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
title_full_unstemmed	Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
title_sort	hesperidin, a flavonoid glycoside with sedative effect, decreases brain perk1/2 levels in mice
url	http://hdl.handle.net/20.500.12110/paper_00913057_v92_n2_p291_Martinez
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Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

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