Novel withanolides from jaborosa sativa

Four new withanolides [1—4] have been isolated from the aerial parts of Jaborosa sativa. Jaborosalactones R[1], S[2], and T [3] contain a hemiketal (or ketal) ring formed between a 21-hydroxyl and a 12-ketone and the characteristic δ-lactone side-chain of the withanolides. Jaborosalactone U [4] poss...

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Detalles Bibliográficos
Autores principales: Bonetto, G.M., Gil, R.R., Oberti, J.C., Veleiro, A.S., Burton, G.
Formato: JOUR
Materias:
jaborosalactone r
jaborosalactone s
jaborosalactone t
jaborosalactone u
trechonolide a
unclassified drug
withanolide
Argentina
article
drug conformation
drug isolation
drug structure
medicinal plant
nonhuman
stereochemistry
Jaborosa
Jaborosa sativa
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v58_n5_p705_Bonetto
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Four new withanolides [1—4] have been isolated from the aerial parts of Jaborosa sativa. Jaborosalactones R[1], S[2], and T [3] contain a hemiketal (or ketal) ring formed between a 21-hydroxyl and a 12-ketone and the characteristic δ-lactone side-chain of the withanolides. Jaborosalactone U [4] possesses an epoxy-γ-lactone side-chain and was identified as the 24,25-epoxy analogue of trechonolide A [5]. © 1995, American Chemical Society. All rights reserved.

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