Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients
The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiom...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01652478_v9_n5_p249_DeTitto |
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todo:paper_01652478_v9_n5_p249_DeTitto2023-10-03T15:02:54Z Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients De Titto, E.H. Braun, M. Lazzari, J.O. Segura, E.L. cell-mediated immunity subcellular antigens Chagas' disease heart antigens T. cruzi blood and hemopoietic system cardiomyopathy cellular immunity chagas disease diagnosis etiology heart human human cell human experiment priority journal protozoon trypanosoma cruzi antigen Adolescent Adult Aged Antigens, Protozoan Chagas Disease Comparative Study Female Human Immunity, Cellular In Vitro Isoantigens Lymphocyte Activation Male Middle Age Myocardium Subcellular Fractions Support, Non-U.S. Gov't Trypanosoma cruzi The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiomyopathic subjects were studied as controls. Lymphoproliferative reactions against heart tissue extracts were detected in 42% of 72 CDP studied, with similar prevalence of positive reactions in all groups, and correlated with reactivity to both liver and kidney homologous tissues (P<0.001). These results confirm the existence of cellular immune reactivity against tissues in CDP, and indicate the lack of organ specificity of this reaction as well as the absence of relation with the clinical state of patients. Cellular reactivity to subcellular fractions of T. cruzi showed a definite pattern according to the clinical status of CDP. Although prevalence of T. cruzi stimulation appeared similar in all groups (70% in CDP-1, 82% in CDP-2 and 75% in CDP-3), CDP-3 showed a significantly higher reactivity to flagellar (69%) and cytosol (63%) fractions than CDP-1 (38 and 27%, respectively). These findings suggest a variable modulation of immune response according to the clinical state of T. cruzi infected subjects. © 1985. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01652478_v9_n5_p249_DeTitto |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cell-mediated immunity subcellular antigens Chagas' disease heart antigens T. cruzi blood and hemopoietic system cardiomyopathy cellular immunity chagas disease diagnosis etiology heart human human cell human experiment priority journal protozoon trypanosoma cruzi antigen Adolescent Adult Aged Antigens, Protozoan Chagas Disease Comparative Study Female Human Immunity, Cellular In Vitro Isoantigens Lymphocyte Activation Male Middle Age Myocardium Subcellular Fractions Support, Non-U.S. Gov't Trypanosoma cruzi |
| spellingShingle |
cell-mediated immunity subcellular antigens Chagas' disease heart antigens T. cruzi blood and hemopoietic system cardiomyopathy cellular immunity chagas disease diagnosis etiology heart human human cell human experiment priority journal protozoon trypanosoma cruzi antigen Adolescent Adult Aged Antigens, Protozoan Chagas Disease Comparative Study Female Human Immunity, Cellular In Vitro Isoantigens Lymphocyte Activation Male Middle Age Myocardium Subcellular Fractions Support, Non-U.S. Gov't Trypanosoma cruzi De Titto, E.H. Braun, M. Lazzari, J.O. Segura, E.L. Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| topic_facet |
cell-mediated immunity subcellular antigens Chagas' disease heart antigens T. cruzi blood and hemopoietic system cardiomyopathy cellular immunity chagas disease diagnosis etiology heart human human cell human experiment priority journal protozoon trypanosoma cruzi antigen Adolescent Adult Aged Antigens, Protozoan Chagas Disease Comparative Study Female Human Immunity, Cellular In Vitro Isoantigens Lymphocyte Activation Male Middle Age Myocardium Subcellular Fractions Support, Non-U.S. Gov't Trypanosoma cruzi |
| description |
The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiomyopathic subjects were studied as controls. Lymphoproliferative reactions against heart tissue extracts were detected in 42% of 72 CDP studied, with similar prevalence of positive reactions in all groups, and correlated with reactivity to both liver and kidney homologous tissues (P<0.001). These results confirm the existence of cellular immune reactivity against tissues in CDP, and indicate the lack of organ specificity of this reaction as well as the absence of relation with the clinical state of patients. Cellular reactivity to subcellular fractions of T. cruzi showed a definite pattern according to the clinical status of CDP. Although prevalence of T. cruzi stimulation appeared similar in all groups (70% in CDP-1, 82% in CDP-2 and 75% in CDP-3), CDP-3 showed a significantly higher reactivity to flagellar (69%) and cytosol (63%) fractions than CDP-1 (38 and 27%, respectively). These findings suggest a variable modulation of immune response according to the clinical state of T. cruzi infected subjects. © 1985. |
| format |
JOUR |
| author |
De Titto, E.H. Braun, M. Lazzari, J.O. Segura, E.L. |
| author_facet |
De Titto, E.H. Braun, M. Lazzari, J.O. Segura, E.L. |
| author_sort |
De Titto, E.H. |
| title |
Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| title_short |
Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| title_full |
Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| title_fullStr |
Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| title_full_unstemmed |
Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients |
| title_sort |
cell-mediated reactivity against human and trypanosoma cruzi antigens according to clinical status in chagas' disease patients |
| url |
http://hdl.handle.net/20.500.12110/paper_01652478_v9_n5_p249_DeTitto |
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