Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients

The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiom...

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Detalles Bibliográficos
Autores principales: De Titto, E.H., Braun, M., Lazzari, J.O., Segura, E.L.
Formato: JOUR
Materias:
cell-mediated immunity subcellular antigens
Chagas' disease
heart antigens
T. cruzi
blood and hemopoietic system
cardiomyopathy
cellular immunity
chagas disease
diagnosis
etiology
heart
human
human cell
human experiment
priority journal
protozoon
trypanosoma cruzi antigen
Adolescent
Adult
Aged
Antigens, Protozoan
Chagas Disease
Comparative Study
Female
Human
Immunity, Cellular
In Vitro
Isoantigens
Lymphocyte Activation
Male
Middle Age
Myocardium
Subcellular Fractions
Support, Non-U.S. Gov't
Trypanosoma cruzi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01652478_v9_n5_p249_DeTitto
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiomyopathic subjects were studied as controls. Lymphoproliferative reactions against heart tissue extracts were detected in 42% of 72 CDP studied, with similar prevalence of positive reactions in all groups, and correlated with reactivity to both liver and kidney homologous tissues (P<0.001). These results confirm the existence of cellular immune reactivity against tissues in CDP, and indicate the lack of organ specificity of this reaction as well as the absence of relation with the clinical state of patients. Cellular reactivity to subcellular fractions of T. cruzi showed a definite pattern according to the clinical status of CDP. Although prevalence of T. cruzi stimulation appeared similar in all groups (70% in CDP-1, 82% in CDP-2 and 75% in CDP-3), CDP-3 showed a significantly higher reactivity to flagellar (69%) and cytosol (63%) fractions than CDP-1 (38 and 27%, respectively). These findings suggest a variable modulation of immune response according to the clinical state of T. cruzi infected subjects. © 1985.

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