Antiviral activity of natural and synthetic β-carbolines against dengue virus

Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural β-carboline harmol and a synthetic harmine de...

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Detalles Bibliográficos
Autores principales: Quintana, V.M., Piccini, L.E., Panozzo Zénere, J.D., Damonte, E.B., Ponce, M.A., Castilla, V.
Formato: JOUR
Materias:
9n methylharmine
antivirus agent
beta carboline derivative
harmine
harmol
harmol acetate
harmol butyrate
harmol caprate
harmol propionate
harmol valerate
mitogen activated protein kinase 14
unclassified drug
virus RNA
beta carboline
carboline derivative
mitogen activated protein kinase p38
adsorption
animal cell
antiviral activity
antiviral susceptibility
Article
cell culture
controlled study
dengue
Dengue virus 2
down regulation
drug effect
drug inhibition
drug screening
enzyme phosphorylation
nonhuman
priority journal
RNA synthesis
serotype
Vero cell line
virogenesis
virus genome
virus inhibition
virus particle
virus release
analogs and derivatives
animal
chemistry
Chlorocebus aethiops
Dengue virus
drug development
drug effects
genetics
human
phosphorylation
synthesis
virus replication
Animals
Antiviral Agents
Carbolines
Cercopithecus aethiops
Dengue Virus
Drug Discovery
Genome, Viral
Harmine
Humans
p38 Mitogen-Activated Protein Kinases
Phosphorylation
RNA, Viral
Vero Cells
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01663542_v134_n_p26_Quintana
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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