Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus
A shadow passing overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus that habituates promptly and for a long period. Robust retention is shown at 24 h after 15 trials of shadow presentation or at 120 h after 30 trials, but no significant retention is disclosed...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01664328_v75_n1-2_p119_Romano |
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todo:paper_01664328_v75_n1-2_p119_Romano2023-10-03T15:03:57Z Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus Romano, A. Delorenzi, A. Pedreira, M.E. Tomsic, D. Maldonado, H. (CPT-cAMP) 8-(4-Chlorophenylthio)cyclic adenosine monophosphate Crustacean Cyclic adenosine monophosphate (cAMP) Learning Long-term habituation Memory 8 (4 chlorophenylthio) cyclic AMP cyclic AMP derivative isobutylmethylxanthine adolescent animal experiment article controlled study crab intramuscular drug administration learning male memory nonhuman priority journal A shadow passing overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus that habituates promptly and for a long period. Robust retention is shown at 24 h after 15 trials of shadow presentation or at 120 h after 30 trials, but no significant retention is disclosed at 24 h after 5 trials or at 72 h after 15. A cocktail of the cAMP membrane permeable analog 8-(4-chlorophenylthio)-cAMP (CPT-cAMP), plus the phosphodiesterase inhibitor isobutyl methylxanthine (IBMX), was given by systemic administration. Pretraining injection of the cocktail (25 or 50 μM, 15 min before a 5-trial session) failed to affect short-term habituation, but induced significant retention when tested at 24 h. This facilitatory effect was not shown when a lower dose (5 μM) was used. A pest-training injection of 25 μM, immediately after a 5- or 15-trial session, induced retention when tested at 24 or 72 h, respectively. Thus, the administration of CPT-cAMP + IBMX during acquisition of a habituated response or immediately after, improves long-term habituation, a result supporting the view that an increase in the cAMP level is one of the steps in long-term memory consolidation. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01664328_v75_n1-2_p119_Romano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
(CPT-cAMP) 8-(4-Chlorophenylthio)cyclic adenosine monophosphate Crustacean Cyclic adenosine monophosphate (cAMP) Learning Long-term habituation Memory 8 (4 chlorophenylthio) cyclic AMP cyclic AMP derivative isobutylmethylxanthine adolescent animal experiment article controlled study crab intramuscular drug administration learning male memory nonhuman priority journal |
| spellingShingle |
(CPT-cAMP) 8-(4-Chlorophenylthio)cyclic adenosine monophosphate Crustacean Cyclic adenosine monophosphate (cAMP) Learning Long-term habituation Memory 8 (4 chlorophenylthio) cyclic AMP cyclic AMP derivative isobutylmethylxanthine adolescent animal experiment article controlled study crab intramuscular drug administration learning male memory nonhuman priority journal Romano, A. Delorenzi, A. Pedreira, M.E. Tomsic, D. Maldonado, H. Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| topic_facet |
(CPT-cAMP) 8-(4-Chlorophenylthio)cyclic adenosine monophosphate Crustacean Cyclic adenosine monophosphate (cAMP) Learning Long-term habituation Memory 8 (4 chlorophenylthio) cyclic AMP cyclic AMP derivative isobutylmethylxanthine adolescent animal experiment article controlled study crab intramuscular drug administration learning male memory nonhuman priority journal |
| description |
A shadow passing overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus that habituates promptly and for a long period. Robust retention is shown at 24 h after 15 trials of shadow presentation or at 120 h after 30 trials, but no significant retention is disclosed at 24 h after 5 trials or at 72 h after 15. A cocktail of the cAMP membrane permeable analog 8-(4-chlorophenylthio)-cAMP (CPT-cAMP), plus the phosphodiesterase inhibitor isobutyl methylxanthine (IBMX), was given by systemic administration. Pretraining injection of the cocktail (25 or 50 μM, 15 min before a 5-trial session) failed to affect short-term habituation, but induced significant retention when tested at 24 h. This facilitatory effect was not shown when a lower dose (5 μM) was used. A pest-training injection of 25 μM, immediately after a 5- or 15-trial session, induced retention when tested at 24 or 72 h, respectively. Thus, the administration of CPT-cAMP + IBMX during acquisition of a habituated response or immediately after, improves long-term habituation, a result supporting the view that an increase in the cAMP level is one of the steps in long-term memory consolidation. |
| format |
JOUR |
| author |
Romano, A. Delorenzi, A. Pedreira, M.E. Tomsic, D. Maldonado, H. |
| author_facet |
Romano, A. Delorenzi, A. Pedreira, M.E. Tomsic, D. Maldonado, H. |
| author_sort |
Romano, A. |
| title |
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| title_short |
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| title_full |
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| title_fullStr |
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| title_full_unstemmed |
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus |
| title_sort |
acute administration of a permeant analog of camp and a phosphodiesterase inhibitor improve long-term habituation in the crab chasmagnathus |
| url |
http://hdl.handle.net/20.500.12110/paper_01664328_v75_n1-2_p119_Romano |
| work_keys_str_mv |
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| _version_ |
1807315393342078976 |