The effect of buffered calcium diffusion on neurotransmitter release

Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest t...

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Detalles Bibliográficos
Autores principales: Ponce Dawson, S., Uchitel, O.D.
Formato: JOUR
Materias:
Calcium
Neurotransmitter
Rapid buffering approximation
Biological membranes
Diffusion
Muscle
Positive ions
Neurotransmitters
Neurology
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_01672789_v168-169_n_p356_PonceDawson
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spelling todo:paper_01672789_v168-169_n_p356_PonceDawson2023-10-03T15:04:36Z The effect of buffered calcium diffusion on neurotransmitter release Ponce Dawson, S. Uchitel, O.D. Calcium Neurotransmitter Rapid buffering approximation Biological membranes Calcium Diffusion Muscle Positive ions Neurotransmitters Neurology Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest that the two types of calcium channels probed in this regard are at different mean distances from the neurotransmitter-containing vesicles. In this work we investigate whether the effect of calcium buffers along the path from the channel to the vesicle sensor can be responsible for the differences observed. Our results show that buffers cannot account for this change. This study also allows us to probe the limitations of the rapid buffering approximation in the presence of strong and localized sources. © 2002 Elsevier Science B.V. All rights reserved. Fil:Ponce Dawson, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Calcium
Neurotransmitter
Rapid buffering approximation
Biological membranes
Calcium
Diffusion
Muscle
Positive ions
Neurotransmitters
Neurology
spellingShingle Calcium
Neurotransmitter
Rapid buffering approximation
Biological membranes
Calcium
Diffusion
Muscle
Positive ions
Neurotransmitters
Neurology
Ponce Dawson, S.
Uchitel, O.D.
The effect of buffered calcium diffusion on neurotransmitter release
topic_facet Calcium
Neurotransmitter
Rapid buffering approximation
Biological membranes
Calcium
Diffusion
Muscle
Positive ions
Neurotransmitters
Neurology
description Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest that the two types of calcium channels probed in this regard are at different mean distances from the neurotransmitter-containing vesicles. In this work we investigate whether the effect of calcium buffers along the path from the channel to the vesicle sensor can be responsible for the differences observed. Our results show that buffers cannot account for this change. This study also allows us to probe the limitations of the rapid buffering approximation in the presence of strong and localized sources. © 2002 Elsevier Science B.V. All rights reserved.
format JOUR
author Ponce Dawson, S.
Uchitel, O.D.
author_facet Ponce Dawson, S.
Uchitel, O.D.
author_sort Ponce Dawson, S.
title The effect of buffered calcium diffusion on neurotransmitter release
title_short The effect of buffered calcium diffusion on neurotransmitter release
title_full The effect of buffered calcium diffusion on neurotransmitter release
title_fullStr The effect of buffered calcium diffusion on neurotransmitter release
title_full_unstemmed The effect of buffered calcium diffusion on neurotransmitter release
title_sort effect of buffered calcium diffusion on neurotransmitter release
url http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
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AT uchitelod theeffectofbufferedcalciumdiffusiononneurotransmitterrelease
AT poncedawsons effectofbufferedcalciumdiffusiononneurotransmitterrelease
AT uchitelod effectofbufferedcalciumdiffusiononneurotransmitterrelease
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