Trypanosoma cruzi serinecarboxipeptidase is a sulfated glycoprotein and a minor antigen in human Chagas disease infection

In this work, the presence of sulfated N-glycans was studied in a high-mannose-type glycoprotein of Trypanosoma cruzi with serinecarboxipeptidase (TcSCP) activity. The immune cross-reactivity between purified SCP and Cruzipain (Cz) was evidenced using rabbit sera specific for both glycoproteins. Tak...

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Detalles Bibliográficos
Autores principales: Soprano, L.L., Parente, J.E., Landoni, M., Couto, A.S., Duschak, V.G.
Formato: JOUR
Materias:
Antigenicity
Chagas’ disease
Glycomics
Serinecarboxypeptidase
Sulfate groups
Sulfotopes
Trypanosoma cruzi
concanavalin A
cruzipain
glycoprotein
serine carboxipeptidase
unclassified drug
carboxypeptidase
cysteine proteinase
parasite antigen
serine carboxypeptidase
sulfate
animal experiment
antigen recognition
Article
Chagas disease
controlled study
cross reaction
deglycosylation
desulfurization
enzyme activity
epimastigote
heart disease
host parasite interaction
human
matrix assisted laser desorption ionization time of flight mass spectrometry
molecular weight
New Zealand White (rabbit)
nonhuman
polyacrylamide gel electrophoresis
priority journal
serum
trypomastigote
ultraviolet spectroscopy
animal
chemistry
enzymology
immunology
Leporidae
mass spectrometry
metabolism
protein processing
Animals
Antigens, Protozoan
Carboxypeptidases
Chagas Disease
Cross Reactions
Cysteine Endopeptidases
Glycoproteins
Humans
Mass Spectrometry
Protein Processing, Post-Translational
Rabbits
Sulfates
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03008584_v207_n2_p117_Soprano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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