Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk
Introduction and objectives Thoracic aorta calcium detection is known to improve cardiovascular risk prediction for cardiac and noncardiac events beyond traditional risk factors. We investigated the influence of thoracic aorta morphometry on the presence and extent of aortic calcifications. Methods...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03008932_v69_n9_p827_Craiem |
| Aporte de: |
| id |
todo:paper_03008932_v69_n9_p827_Craiem |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_03008932_v69_n9_p827_Craiem2023-10-03T15:17:55Z Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk Craiem, D. Alsac, J.-M. Casciaro, M.E. El Batti, S. Mousseaux, E. Sirieix, M.-E. Simon, A. Aorta Atherosclerosis Calcium Computed tomography calcium Aortic Diseases asymptomatic disease Cardiovascular Diseases clinical trial diagnostic imaging female health human incidence male metabolism middle aged multicenter study multidetector computed tomography procedures retrospective study risk assessment risk factor thoracic aorta Aorta, Thoracic Aortic Diseases Asymptomatic Diseases Calcium Cardiovascular Diseases Female Global Health Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Risk Factors Introduction and objectives Thoracic aorta calcium detection is known to improve cardiovascular risk prediction for cardiac and noncardiac events beyond traditional risk factors. We investigated the influence of thoracic aorta morphometry on the presence and extent of aortic calcifications. Methods Nonenhanced computed tomography heart scans were performed in 970 asymptomatic participants at increased cardiovascular risk. An automated algorithm estimated the geometry of the entire thoracic aorta and quantified the aortic calcium Agatston score. A nonparametric model was used to analyze the percentiles of calcium score by age. Logistic regression models were calculated to identify anatomical associations with calcium levels. Results Calcifications were concentrated in the aortic arch and descending portions. Higher amounts of calcium were associated with an enlarged, unfolded, less tapered and more tortuous aorta. The size of the ascending aorta was not correlated with aortic calcium score, whereas enlargement of the descending aorta had the strongest association: the risk of having a global calcium score > 90th percentile was 3.62 times higher (confidence interval, 2.30-5.91; P < .001) for each 2.5-mm increase in descending aorta diameter. Vessel taper, tortuosity, unfolding and aortic arch and descending volumes were also correlated with higher amounts of calcium. Conclusions Thoracic aorta calcium was predominantly found at the arch and descending aorta and was positively associated with the size of the descending aorta and the aortic arch, but not with the size of the ascending aorta. These findings suggest that aortic dilatation may have different mechanisms and may consequently require different preventive strategies according to the considered segments. Full English text available from: www.revespcardiol.org/en © 2016 Sociedad Española de Cardiología JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03008932_v69_n9_p827_Craiem |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Aorta Atherosclerosis Calcium Computed tomography calcium Aortic Diseases asymptomatic disease Cardiovascular Diseases clinical trial diagnostic imaging female health human incidence male metabolism middle aged multicenter study multidetector computed tomography procedures retrospective study risk assessment risk factor thoracic aorta Aorta, Thoracic Aortic Diseases Asymptomatic Diseases Calcium Cardiovascular Diseases Female Global Health Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Risk Factors |
| spellingShingle |
Aorta Atherosclerosis Calcium Computed tomography calcium Aortic Diseases asymptomatic disease Cardiovascular Diseases clinical trial diagnostic imaging female health human incidence male metabolism middle aged multicenter study multidetector computed tomography procedures retrospective study risk assessment risk factor thoracic aorta Aorta, Thoracic Aortic Diseases Asymptomatic Diseases Calcium Cardiovascular Diseases Female Global Health Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Risk Factors Craiem, D. Alsac, J.-M. Casciaro, M.E. El Batti, S. Mousseaux, E. Sirieix, M.-E. Simon, A. Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| topic_facet |
Aorta Atherosclerosis Calcium Computed tomography calcium Aortic Diseases asymptomatic disease Cardiovascular Diseases clinical trial diagnostic imaging female health human incidence male metabolism middle aged multicenter study multidetector computed tomography procedures retrospective study risk assessment risk factor thoracic aorta Aorta, Thoracic Aortic Diseases Asymptomatic Diseases Calcium Cardiovascular Diseases Female Global Health Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Risk Factors |
| description |
Introduction and objectives Thoracic aorta calcium detection is known to improve cardiovascular risk prediction for cardiac and noncardiac events beyond traditional risk factors. We investigated the influence of thoracic aorta morphometry on the presence and extent of aortic calcifications. Methods Nonenhanced computed tomography heart scans were performed in 970 asymptomatic participants at increased cardiovascular risk. An automated algorithm estimated the geometry of the entire thoracic aorta and quantified the aortic calcium Agatston score. A nonparametric model was used to analyze the percentiles of calcium score by age. Logistic regression models were calculated to identify anatomical associations with calcium levels. Results Calcifications were concentrated in the aortic arch and descending portions. Higher amounts of calcium were associated with an enlarged, unfolded, less tapered and more tortuous aorta. The size of the ascending aorta was not correlated with aortic calcium score, whereas enlargement of the descending aorta had the strongest association: the risk of having a global calcium score > 90th percentile was 3.62 times higher (confidence interval, 2.30-5.91; P < .001) for each 2.5-mm increase in descending aorta diameter. Vessel taper, tortuosity, unfolding and aortic arch and descending volumes were also correlated with higher amounts of calcium. Conclusions Thoracic aorta calcium was predominantly found at the arch and descending aorta and was positively associated with the size of the descending aorta and the aortic arch, but not with the size of the ascending aorta. These findings suggest that aortic dilatation may have different mechanisms and may consequently require different preventive strategies according to the considered segments. Full English text available from: www.revespcardiol.org/en © 2016 Sociedad Española de Cardiología |
| format |
JOUR |
| author |
Craiem, D. Alsac, J.-M. Casciaro, M.E. El Batti, S. Mousseaux, E. Sirieix, M.-E. Simon, A. |
| author_facet |
Craiem, D. Alsac, J.-M. Casciaro, M.E. El Batti, S. Mousseaux, E. Sirieix, M.-E. Simon, A. |
| author_sort |
Craiem, D. |
| title |
Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| title_short |
Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| title_full |
Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| title_fullStr |
Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| title_full_unstemmed |
Association Between Thoracic Aorta Calcium and Thoracic Aorta Geometry in a Cohort of Asymptomatic Participants at Increased Cardiovascular Risk |
| title_sort |
association between thoracic aorta calcium and thoracic aorta geometry in a cohort of asymptomatic participants at increased cardiovascular risk |
| url |
http://hdl.handle.net/20.500.12110/paper_03008932_v69_n9_p827_Craiem |
| work_keys_str_mv |
AT craiemd associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT alsacjm associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT casciarome associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT elbattis associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT mousseauxe associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT sirieixme associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk AT simona associationbetweenthoracicaortacalciumandthoracicaortageometryinacohortofasymptomaticparticipantsatincreasedcardiovascularrisk |
| _version_ |
1807317058937946112 |