Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function
The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rat...
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todo:paper_03013073_v35_n_p157_DeNicola2023-10-03T15:18:17Z Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function De Nicola, A.F. Saravia, F.E. Beauquis, J. Pietranera, L. Ferrini, M.G. Arzt E. Guitelman M Bronstein M. estrogen steroid adrenal gland aging animal cholinergic nerve conference paper drug effect feedback system forebrain hippocampus human hypophysis adrenal system hypothalamus hypophysis system metabolism neurosecretion physiology rat Adrenal Glands Aging Animals Cholinergic Fibers Estrogens Feedback, Biochemical Hippocampus Humans Hypothalamo-Hypophyseal System Neurosecretory Systems Pituitary-Adrenal System Prosencephalon Rats Steroids The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rats, in which abnormalities of the HPA axis included altered response to stress, reduced effectiveness of the steroid negative feedback and low expression of hippocampal glucocorticoid receptors (GR). Estrogen treatment of aging rats normalized the response to stress, restored the dexamethasone inhibition of the stress response and increased GR density in defined hippocampal areas. Although estrogens could influence the hippocampus of aging animals directly, their effects could be also mediated by estrogen-sensitive forebrain cholinergic neurons projecting to the hippocampus. Additionally, estrogens normalized the deficient granule cell proliferation that aging mice present in the dentate gyrus, and attenuated several markers of hippocampal aging, such as astrocytosis, high lipofucsin content and neuronal loss in the hilus of the dentate gyrus. These effects may be important for the regulation of the HPA axis, in the context that hippocampal function as a whole was normalized by estrogen action. Therefore, estrogens are powerful neuroprotectants in cases of hippocampal dysfunction, and as part of this effect, they contribute to stabilize the function of the HPA axis. Copyright © 2006 S. Karger AG. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p157_DeNicola |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
estrogen steroid adrenal gland aging animal cholinergic nerve conference paper drug effect feedback system forebrain hippocampus human hypophysis adrenal system hypothalamus hypophysis system metabolism neurosecretion physiology rat Adrenal Glands Aging Animals Cholinergic Fibers Estrogens Feedback, Biochemical Hippocampus Humans Hypothalamo-Hypophyseal System Neurosecretory Systems Pituitary-Adrenal System Prosencephalon Rats Steroids |
| spellingShingle |
estrogen steroid adrenal gland aging animal cholinergic nerve conference paper drug effect feedback system forebrain hippocampus human hypophysis adrenal system hypothalamus hypophysis system metabolism neurosecretion physiology rat Adrenal Glands Aging Animals Cholinergic Fibers Estrogens Feedback, Biochemical Hippocampus Humans Hypothalamo-Hypophyseal System Neurosecretory Systems Pituitary-Adrenal System Prosencephalon Rats Steroids De Nicola, A.F. Saravia, F.E. Beauquis, J. Pietranera, L. Ferrini, M.G. Arzt E. Guitelman M Bronstein M. Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| topic_facet |
estrogen steroid adrenal gland aging animal cholinergic nerve conference paper drug effect feedback system forebrain hippocampus human hypophysis adrenal system hypothalamus hypophysis system metabolism neurosecretion physiology rat Adrenal Glands Aging Animals Cholinergic Fibers Estrogens Feedback, Biochemical Hippocampus Humans Hypothalamo-Hypophyseal System Neurosecretory Systems Pituitary-Adrenal System Prosencephalon Rats Steroids |
| description |
The function of the HPA axis is subject to regulation by many factors, which achieve relevance under normal and pathological conditions. In the case of aging, this period of life is associated with disturbances of the HPA axis and signs of hippocampal vulnerability. We examined 20-month-old male rats, in which abnormalities of the HPA axis included altered response to stress, reduced effectiveness of the steroid negative feedback and low expression of hippocampal glucocorticoid receptors (GR). Estrogen treatment of aging rats normalized the response to stress, restored the dexamethasone inhibition of the stress response and increased GR density in defined hippocampal areas. Although estrogens could influence the hippocampus of aging animals directly, their effects could be also mediated by estrogen-sensitive forebrain cholinergic neurons projecting to the hippocampus. Additionally, estrogens normalized the deficient granule cell proliferation that aging mice present in the dentate gyrus, and attenuated several markers of hippocampal aging, such as astrocytosis, high lipofucsin content and neuronal loss in the hilus of the dentate gyrus. These effects may be important for the regulation of the HPA axis, in the context that hippocampal function as a whole was normalized by estrogen action. Therefore, estrogens are powerful neuroprotectants in cases of hippocampal dysfunction, and as part of this effect, they contribute to stabilize the function of the HPA axis. Copyright © 2006 S. Karger AG. |
| format |
SER |
| author |
De Nicola, A.F. Saravia, F.E. Beauquis, J. Pietranera, L. Ferrini, M.G. Arzt E. Guitelman M Bronstein M. |
| author_facet |
De Nicola, A.F. Saravia, F.E. Beauquis, J. Pietranera, L. Ferrini, M.G. Arzt E. Guitelman M Bronstein M. |
| author_sort |
De Nicola, A.F. |
| title |
Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| title_short |
Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| title_full |
Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| title_fullStr |
Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| title_full_unstemmed |
Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| title_sort |
estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function |
| url |
http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p157_DeNicola |
| work_keys_str_mv |
AT denicolaaf estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT saraviafe estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT beauquisj estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT pietraneral estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT ferrinimg estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT arzte estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT guitelmanm estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction AT bronsteinm estrogensandneuroendocrinehypothalamicpituitaryadrenalaxisfunction |
| _version_ |
1807321667363405824 |