Bone morphogenetic protein-4 control of pituitary pathophysiology

Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen rec...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A.C., Chervin, A., Berner, S., Labeur, M., Refojo, D., Renner, U., Stalla, G.K., Arzt, E.
Formato: SER
Materias:
bone morphogenetic protein
bone morphogenetic protein 4
corticotropin
retinoic acid
transforming growth factor beta
transforming growth factor beta receptor
animal
biological model
conference paper
cytology
gene expression
growth, development and aging
human
hypophysis
hypophysis disease
metabolism
nerve cell
physiology
secretion
Adrenocorticotropic Hormone
Animals
Bone Morphogenetic Proteins
Gene Expression
Humans
Models, Biological
Neurons
Pituitary Diseases
Pituitary Gland
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Tretinoin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03013073_v35_n_p22_Giacomini
record_format dspace
spelling todo:paper_03013073_v35_n_p22_Giacomini2023-10-03T15:18:18Z Bone morphogenetic protein-4 control of pituitary pathophysiology Giacomini, D. Páez-Pereda, M. Theodoropoulou, M. Gerez, J. Nagashima, A.C. Chervin, A. Berner, S. Labeur, M. Refojo, D. Renner, U. Stalla, G.K. Arzt, E. bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Páez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gerez, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic bone morphogenetic protein
bone morphogenetic protein 4
corticotropin
retinoic acid
transforming growth factor beta
transforming growth factor beta receptor
animal
biological model
conference paper
cytology
gene expression
growth, development and aging
human
hypophysis
hypophysis disease
metabolism
nerve cell
physiology
secretion
Adrenocorticotropic Hormone
Animals
Bone Morphogenetic Proteins
Gene Expression
Humans
Models, Biological
Neurons
Pituitary Diseases
Pituitary Gland
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Tretinoin
spellingShingle bone morphogenetic protein
bone morphogenetic protein 4
corticotropin
retinoic acid
transforming growth factor beta
transforming growth factor beta receptor
animal
biological model
conference paper
cytology
gene expression
growth, development and aging
human
hypophysis
hypophysis disease
metabolism
nerve cell
physiology
secretion
Adrenocorticotropic Hormone
Animals
Bone Morphogenetic Proteins
Gene Expression
Humans
Models, Biological
Neurons
Pituitary Diseases
Pituitary Gland
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Tretinoin
Giacomini, D.
Páez-Pereda, M.
Theodoropoulou, M.
Gerez, J.
Nagashima, A.C.
Chervin, A.
Berner, S.
Labeur, M.
Refojo, D.
Renner, U.
Stalla, G.K.
Arzt, E.
Bone morphogenetic protein-4 control of pituitary pathophysiology
topic_facet bone morphogenetic protein
bone morphogenetic protein 4
corticotropin
retinoic acid
transforming growth factor beta
transforming growth factor beta receptor
animal
biological model
conference paper
cytology
gene expression
growth, development and aging
human
hypophysis
hypophysis disease
metabolism
nerve cell
physiology
secretion
Adrenocorticotropic Hormone
Animals
Bone Morphogenetic Proteins
Gene Expression
Humans
Models, Biological
Neurons
Pituitary Diseases
Pituitary Gland
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Tretinoin
description Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG.
format SER
author Giacomini, D.
Páez-Pereda, M.
Theodoropoulou, M.
Gerez, J.
Nagashima, A.C.
Chervin, A.
Berner, S.
Labeur, M.
Refojo, D.
Renner, U.
Stalla, G.K.
Arzt, E.
author_facet Giacomini, D.
Páez-Pereda, M.
Theodoropoulou, M.
Gerez, J.
Nagashima, A.C.
Chervin, A.
Berner, S.
Labeur, M.
Refojo, D.
Renner, U.
Stalla, G.K.
Arzt, E.
author_sort Giacomini, D.
title Bone morphogenetic protein-4 control of pituitary pathophysiology
title_short Bone morphogenetic protein-4 control of pituitary pathophysiology
title_full Bone morphogenetic protein-4 control of pituitary pathophysiology
title_fullStr Bone morphogenetic protein-4 control of pituitary pathophysiology
title_full_unstemmed Bone morphogenetic protein-4 control of pituitary pathophysiology
title_sort bone morphogenetic protein-4 control of pituitary pathophysiology
url http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
work_keys_str_mv AT giacominid bonemorphogeneticprotein4controlofpituitarypathophysiology
AT paezperedam bonemorphogeneticprotein4controlofpituitarypathophysiology
AT theodoropouloum bonemorphogeneticprotein4controlofpituitarypathophysiology
AT gerezj bonemorphogeneticprotein4controlofpituitarypathophysiology
AT nagashimaac bonemorphogeneticprotein4controlofpituitarypathophysiology
AT chervina bonemorphogeneticprotein4controlofpituitarypathophysiology
AT berners bonemorphogeneticprotein4controlofpituitarypathophysiology
AT labeurm bonemorphogeneticprotein4controlofpituitarypathophysiology
AT refojod bonemorphogeneticprotein4controlofpituitarypathophysiology
AT renneru bonemorphogeneticprotein4controlofpituitarypathophysiology
AT stallagk bonemorphogeneticprotein4controlofpituitarypathophysiology
AT arzte bonemorphogeneticprotein4controlofpituitarypathophysiology
_version_ 1807314658914205696

Ejemplares similares