Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis
Cystic echinococcosis is a chronic, complex, and still neglected disease. Although albendazole has demonstrated efficacy, only about one-third of patients experience complete remission or cure and 30-50% of treated patients develop some evidence of a therapeutic response. Different strategies have b...
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todo:paper_03044017_v203_n1-2_p80_Pensel2023-10-03T15:20:35Z Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis Pensel, P.E. Castro, S. Allemandi, D. Bruni, S.S. Palma, S.D. Elissondo, M.C. Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions albendazole sulfoxide placebo poloxamer animal experiment animal model animal tissue anthelmintic activity article clinical effectiveness controlled study drug bioavailability drug efficacy drug formulation echinococcosis Echinococcus granulosus in vivo study infection prevention metacestode microbial morphology mouse nonhuman parasite identification treatment outcome Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions Albendazole Animals Anthelmintics Chemoprevention Echinococcosis Echinococcus granulosus Microscopy, Electron, Scanning Microscopy, Electron, Transmission Poloxamer Treatment Outcome Cystic echinococcosis is a chronic, complex, and still neglected disease. Although albendazole has demonstrated efficacy, only about one-third of patients experience complete remission or cure and 30-50% of treated patients develop some evidence of a therapeutic response. Different strategies have been developed in order to improve the albendazole water solubility and dissolution rate. The aim of the current work was to investigate the chemoprophylactic and clinical efficacy of an albendazole:poloxamer 188 solid dispersion formulation on mice infected with Echinococcus granulosus metacestodes. Albendazole formulated as solid dispersion had greater chemoprophylactic and clinical efficacy than albendazole alone. The improved in therapeutic efficacy could be a consequence of the increase in the systemic availability of albendazole sulfoxide. The work reported here demonstrates that in vivo treatment with albendazole:poloxamer 188 impairs the development of the hydatid cysts. This new pharmacotechnically based strategy could be a suitable alternative for treating cystic echinococcosis in humans. © 2014 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03044017_v203_n1-2_p80_Pensel |
| institution |
Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions albendazole sulfoxide placebo poloxamer animal experiment animal model animal tissue anthelmintic activity article clinical effectiveness controlled study drug bioavailability drug efficacy drug formulation echinococcosis Echinococcus granulosus in vivo study infection prevention metacestode microbial morphology mouse nonhuman parasite identification treatment outcome Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions Albendazole Animals Anthelmintics Chemoprevention Echinococcosis Echinococcus granulosus Microscopy, Electron, Scanning Microscopy, Electron, Transmission Poloxamer Treatment Outcome |
| spellingShingle |
Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions albendazole sulfoxide placebo poloxamer animal experiment animal model animal tissue anthelmintic activity article clinical effectiveness controlled study drug bioavailability drug efficacy drug formulation echinococcosis Echinococcus granulosus in vivo study infection prevention metacestode microbial morphology mouse nonhuman parasite identification treatment outcome Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions Albendazole Animals Anthelmintics Chemoprevention Echinococcosis Echinococcus granulosus Microscopy, Electron, Scanning Microscopy, Electron, Transmission Poloxamer Treatment Outcome Pensel, P.E. Castro, S. Allemandi, D. Bruni, S.S. Palma, S.D. Elissondo, M.C. Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| topic_facet |
Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions albendazole sulfoxide placebo poloxamer animal experiment animal model animal tissue anthelmintic activity article clinical effectiveness controlled study drug bioavailability drug efficacy drug formulation echinococcosis Echinococcus granulosus in vivo study infection prevention metacestode microbial morphology mouse nonhuman parasite identification treatment outcome Albendazole Cystic echinococcosis Echinococcus granulosus Solid dispersions Albendazole Animals Anthelmintics Chemoprevention Echinococcosis Echinococcus granulosus Microscopy, Electron, Scanning Microscopy, Electron, Transmission Poloxamer Treatment Outcome |
| description |
Cystic echinococcosis is a chronic, complex, and still neglected disease. Although albendazole has demonstrated efficacy, only about one-third of patients experience complete remission or cure and 30-50% of treated patients develop some evidence of a therapeutic response. Different strategies have been developed in order to improve the albendazole water solubility and dissolution rate. The aim of the current work was to investigate the chemoprophylactic and clinical efficacy of an albendazole:poloxamer 188 solid dispersion formulation on mice infected with Echinococcus granulosus metacestodes. Albendazole formulated as solid dispersion had greater chemoprophylactic and clinical efficacy than albendazole alone. The improved in therapeutic efficacy could be a consequence of the increase in the systemic availability of albendazole sulfoxide. The work reported here demonstrates that in vivo treatment with albendazole:poloxamer 188 impairs the development of the hydatid cysts. This new pharmacotechnically based strategy could be a suitable alternative for treating cystic echinococcosis in humans. © 2014 Elsevier B.V. |
| format |
JOUR |
| author |
Pensel, P.E. Castro, S. Allemandi, D. Bruni, S.S. Palma, S.D. Elissondo, M.C. |
| author_facet |
Pensel, P.E. Castro, S. Allemandi, D. Bruni, S.S. Palma, S.D. Elissondo, M.C. |
| author_sort |
Pensel, P.E. |
| title |
Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| title_short |
Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| title_full |
Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| title_fullStr |
Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| title_full_unstemmed |
Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| title_sort |
enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis |
| url |
http://hdl.handle.net/20.500.12110/paper_03044017_v203_n1-2_p80_Pensel |
| work_keys_str_mv |
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| _version_ |
1807319583517835264 |