Effect of multiple doses of volatile anesthetics on heme enzymes
1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead...
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todo:paper_03063623_v25_n6_p1179_Buzaleh2023-10-03T15:22:14Z Effect of multiple doses of volatile anesthetics on heme enzymes Buzaleh, A.M. Enriquez de Salamanca, R. Del Batlle, C.A.M. acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't 1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level. © 1994. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Batlle, C.A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v25_n6_p1179_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't |
| spellingShingle |
acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't Buzaleh, A.M. Enriquez de Salamanca, R. Del Batlle, C.A.M. Effect of multiple doses of volatile anesthetics on heme enzymes |
| topic_facet |
acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't |
| description |
1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level. © 1994. |
| format |
JOUR |
| author |
Buzaleh, A.M. Enriquez de Salamanca, R. Del Batlle, C.A.M. |
| author_facet |
Buzaleh, A.M. Enriquez de Salamanca, R. Del Batlle, C.A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Effect of multiple doses of volatile anesthetics on heme enzymes |
| title_short |
Effect of multiple doses of volatile anesthetics on heme enzymes |
| title_full |
Effect of multiple doses of volatile anesthetics on heme enzymes |
| title_fullStr |
Effect of multiple doses of volatile anesthetics on heme enzymes |
| title_full_unstemmed |
Effect of multiple doses of volatile anesthetics on heme enzymes |
| title_sort |
effect of multiple doses of volatile anesthetics on heme enzymes |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v25_n6_p1179_Buzaleh |
| work_keys_str_mv |
AT buzaleham effectofmultipledosesofvolatileanestheticsonhemeenzymes AT enriquezdesalamancar effectofmultipledosesofvolatileanestheticsonhemeenzymes AT delbatllecam effectofmultipledosesofvolatileanestheticsonhemeenzymes |
| _version_ |
1807317775994060800 |