Griseofulvin-induced hepatopathy due to abnormalities in heme pathways

1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) in...

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Autores principales:	Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M.
Formato:	JOUR
Materias:	Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03063623_v29_n2_p207_Polo2023-10-03T15:22:16Z Griseofulvin-induced hepatopathy due to abnormalities in heme pathways Polo, C.F. Buzaleh, A.M. Vazquez, E.S. Afonso, S.G. Navone, N.M. Del Carmen Batlle, A.M. Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice 1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice
spellingShingle	Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice Polo, C.F. Buzaleh, A.M. Vazquez, E.S. Afonso, S.G. Navone, N.M. Del Carmen Batlle, A.M. Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
topic_facet	Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice
description	1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics.
format	JOUR
author	Polo, C.F. Buzaleh, A.M. Vazquez, E.S. Afonso, S.G. Navone, N.M. Del Carmen Batlle, A.M.
author_facet	Polo, C.F. Buzaleh, A.M. Vazquez, E.S. Afonso, S.G. Navone, N.M. Del Carmen Batlle, A.M.
author_sort	Polo, C.F.
title	Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
title_short	Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
title_full	Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
title_fullStr	Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
title_full_unstemmed	Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
title_sort	griseofulvin-induced hepatopathy due to abnormalities in heme pathways
url	http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo
work_keys_str_mv	AT polocf griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways AT buzaleham griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways AT vazquezes griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways AT afonsosg griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways AT navonenm griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways AT delcarmenbatlleam griseofulvininducedhepatopathyduetoabnormalitiesinhemepathways
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Griseofulvin-induced hepatopathy due to abnormalities in heme pathways

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