Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) in...
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| Autores principales: | , , , , , |
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| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo |
| Aporte de: |
| Sumario: | 1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics. |
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