Griseofulvin-induced hepatopathy due to abnormalities in heme pathways

1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) in...

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Detalles Bibliográficos
Autores principales: Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M.
Formato: JOUR
Materias:
Cholestasis
Griseofulvan
Heme pathway
Hepatopathy
alkaline phosphatase
aspartate aminotransferase
bilirubin
bilirubin glucuronide
griseofulvin
heme
porphyrin
xenobiotic agent
animal experiment
animal tissue
article
cholestasis
controlled study
liver disease
liver injury
liver level
long term exposure
male
microscopy
mouse
nonhuman
priority journal
topical drug administration
Administration, Topical
Animals
Antibiotics, Antifungal
Biological Markers
Griseofulvin
Heme
Liver
Liver Function Tests
Male
Mice
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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