δ-Aminolevulinic acid transport through blood-brain barrier
δ-Aminolevulinic acid (ALA) and γ-aminobutyric acid (GABA) transport through the rat blood-brain barrier (BBB) was studied.GABA transport (K(m)=3.2±0.1 μM and V(max)=0.299±0.045 μmol/mg protein min) is probably mediated by a permease similar to Saccharomyces cerevisise PUT4; this result also indicat...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03063623_v31_n4_p579_Garcia |
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todo:paper_03063623_v31_n4_p579_Garcia2023-10-03T15:22:17Z δ-Aminolevulinic acid transport through blood-brain barrier García, S.C. Moretti, M.B. Garay, M.V.R. Batlle, A. γ-Aminobutyric acid δ-Aminolevulinic acid Biological transport Blood-brain barrier PUT4 permease UGA4 permease 2 amino 2 methylpropionic acid 4 aminobutyric acid acexamic acid aminolevulinic acid beta alanine carrier protein leucine ouabain proline 4 aminobutyric acid uptake animal tissue article blood brain barrier drug transport endothelium cell male nonhuman priority journal rat transport at the cellular level Aminolevulinic Acid Animals Blood-Brain Barrier Capillary Permeability gamma-Aminobutyric Acid Male Rats Rats, Sprague-Dawley δ-Aminolevulinic acid (ALA) and γ-aminobutyric acid (GABA) transport through the rat blood-brain barrier (BBB) was studied.GABA transport (K(m)=3.2±0.1 μM and V(max)=0.299±0.045 μmol/mg protein min) is probably mediated by a permease similar to Saccharomyces cerevisise PUT4; this result also indicates that the isolated capillaries are metabolically active.ALA incorporation into rat brain endothelial cells is not detected even in capillaries treated to expose the luminal surface.Previous evidence indicates that ALA can cross the BBB from blood to brain; so we conclude that, with the methodology used here, transport in the luminal membrane of the capillaries cannot be investigated. Copyright (C) 1998 Elsevier Science Inc. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v31_n4_p579_Garcia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
γ-Aminobutyric acid δ-Aminolevulinic acid Biological transport Blood-brain barrier PUT4 permease UGA4 permease 2 amino 2 methylpropionic acid 4 aminobutyric acid acexamic acid aminolevulinic acid beta alanine carrier protein leucine ouabain proline 4 aminobutyric acid uptake animal tissue article blood brain barrier drug transport endothelium cell male nonhuman priority journal rat transport at the cellular level Aminolevulinic Acid Animals Blood-Brain Barrier Capillary Permeability gamma-Aminobutyric Acid Male Rats Rats, Sprague-Dawley |
| spellingShingle |
γ-Aminobutyric acid δ-Aminolevulinic acid Biological transport Blood-brain barrier PUT4 permease UGA4 permease 2 amino 2 methylpropionic acid 4 aminobutyric acid acexamic acid aminolevulinic acid beta alanine carrier protein leucine ouabain proline 4 aminobutyric acid uptake animal tissue article blood brain barrier drug transport endothelium cell male nonhuman priority journal rat transport at the cellular level Aminolevulinic Acid Animals Blood-Brain Barrier Capillary Permeability gamma-Aminobutyric Acid Male Rats Rats, Sprague-Dawley García, S.C. Moretti, M.B. Garay, M.V.R. Batlle, A. δ-Aminolevulinic acid transport through blood-brain barrier |
| topic_facet |
γ-Aminobutyric acid δ-Aminolevulinic acid Biological transport Blood-brain barrier PUT4 permease UGA4 permease 2 amino 2 methylpropionic acid 4 aminobutyric acid acexamic acid aminolevulinic acid beta alanine carrier protein leucine ouabain proline 4 aminobutyric acid uptake animal tissue article blood brain barrier drug transport endothelium cell male nonhuman priority journal rat transport at the cellular level Aminolevulinic Acid Animals Blood-Brain Barrier Capillary Permeability gamma-Aminobutyric Acid Male Rats Rats, Sprague-Dawley |
| description |
δ-Aminolevulinic acid (ALA) and γ-aminobutyric acid (GABA) transport through the rat blood-brain barrier (BBB) was studied.GABA transport (K(m)=3.2±0.1 μM and V(max)=0.299±0.045 μmol/mg protein min) is probably mediated by a permease similar to Saccharomyces cerevisise PUT4; this result also indicates that the isolated capillaries are metabolically active.ALA incorporation into rat brain endothelial cells is not detected even in capillaries treated to expose the luminal surface.Previous evidence indicates that ALA can cross the BBB from blood to brain; so we conclude that, with the methodology used here, transport in the luminal membrane of the capillaries cannot be investigated. Copyright (C) 1998 Elsevier Science Inc. |
| format |
JOUR |
| author |
García, S.C. Moretti, M.B. Garay, M.V.R. Batlle, A. |
| author_facet |
García, S.C. Moretti, M.B. Garay, M.V.R. Batlle, A. |
| author_sort |
García, S.C. |
| title |
δ-Aminolevulinic acid transport through blood-brain barrier |
| title_short |
δ-Aminolevulinic acid transport through blood-brain barrier |
| title_full |
δ-Aminolevulinic acid transport through blood-brain barrier |
| title_fullStr |
δ-Aminolevulinic acid transport through blood-brain barrier |
| title_full_unstemmed |
δ-Aminolevulinic acid transport through blood-brain barrier |
| title_sort |
δ-aminolevulinic acid transport through blood-brain barrier |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v31_n4_p579_Garcia |
| work_keys_str_mv |
AT garciasc daminolevulinicacidtransportthroughbloodbrainbarrier AT morettimb daminolevulinicacidtransportthroughbloodbrainbarrier AT garaymvr daminolevulinicacidtransportthroughbloodbrainbarrier AT batllea daminolevulinicacidtransportthroughbloodbrainbarrier |
| _version_ |
1807315592044085248 |