Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?

The fibrinogen (Fbg) molecule is a dimer, consisting of three pairs of different polypeptide chains. In the coagulation cascade, Fbg is converted into fibrin. It is an acute phase protein that is involved in several cellular interactions:platelet aggregation, blood rheology, pinocytosis, cell growth...

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Autor principal: Quintana, I.L.
Formato: JOUR
Materias:
Atherosclerosis
Fibrinogen
Marker of activation
Risk factor
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p13_Quintana
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03252957_v32_n1_p13_Quintana
record_format dspace
spelling todo:paper_03252957_v32_n1_p13_Quintana2023-10-03T15:23:32Z Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular? Quintana, I.L. Atherosclerosis Fibrinogen Marker of activation Risk factor The fibrinogen (Fbg) molecule is a dimer, consisting of three pairs of different polypeptide chains. In the coagulation cascade, Fbg is converted into fibrin. It is an acute phase protein that is involved in several cellular interactions:platelet aggregation, blood rheology, pinocytosis, cell growth, cell migration, chemotaxis and endothelial cell injury. Fibrinogen biosynthesis by hepatocytes is controlled by "hepatocyte stimulating factors" (Interleukin-6, Leukemia Inhibitor Factor and Oncostatin M). Several epidemiological studies have demonstrated a positive statistical correlation of the plasma Fbg level with subsequent ischemic cardiovascular events. Fbg is associated with cholesterol, glycemia, blood pressure, smoking, alcohol, age. It has not been clearly established whether the increase in Fbg levels is a risk factor or merely a marker of vascular desease. Fil:Quintana, I.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p13_Quintana
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Atherosclerosis
Fibrinogen
Marker of activation
Risk factor
spellingShingle Atherosclerosis
Fibrinogen
Marker of activation
Risk factor
Quintana, I.L.
Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
topic_facet Atherosclerosis
Fibrinogen
Marker of activation
Risk factor
description The fibrinogen (Fbg) molecule is a dimer, consisting of three pairs of different polypeptide chains. In the coagulation cascade, Fbg is converted into fibrin. It is an acute phase protein that is involved in several cellular interactions:platelet aggregation, blood rheology, pinocytosis, cell growth, cell migration, chemotaxis and endothelial cell injury. Fibrinogen biosynthesis by hepatocytes is controlled by "hepatocyte stimulating factors" (Interleukin-6, Leukemia Inhibitor Factor and Oncostatin M). Several epidemiological studies have demonstrated a positive statistical correlation of the plasma Fbg level with subsequent ischemic cardiovascular events. Fbg is associated with cholesterol, glycemia, blood pressure, smoking, alcohol, age. It has not been clearly established whether the increase in Fbg levels is a risk factor or merely a marker of vascular desease.
format JOUR
author Quintana, I.L.
author_facet Quintana, I.L.
author_sort Quintana, I.L.
title Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
title_short Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
title_full Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
title_fullStr Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
title_full_unstemmed Fibrinógeno. ¿Factor de riesgo o marcador de enfermedad vascular?
title_sort fibrinógeno. ¿factor de riesgo o marcador de enfermedad vascular?
url http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p13_Quintana
work_keys_str_mv AT quintanail fibrinogenofactorderiesgoomarcadordeenfermedadvascular
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