Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil

In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the dis...

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Autores principales:	de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., Cabrera, G.M., Palermo, J.A., Reginatto, F.H., Steindel, M., Schenkel, E.P.
Formato:	JOUR
Materias:	Antiprotozoal Carijoa riisei Leishmania braziliensis Octocoral Pregnane sterol Trypanosoma cruzi alcohol amphotericin B ampicillin antibiotic agent antifungal agent antiprotozoal agent benznidazole butanol Carijoa riisei extract ceftazidime chloramphenicol cloxacillin fluconazole hexane imipenem levofloxacin oxacillin plant extract pregna 1,4,20 trien 3 one pregnane derivative unclassified drug water animal cell antibacterial activity antifungal activity antimicrobial activity antiprotozoal activity article bacterial growth Brazil controlled study coral reef cytotoxicity test disk diffusion drug screening drug structure epimastigote fungus growth growth inhibition in vitro study mouse nonhuman promastigote Staphylococcus aureus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03262383_v31_n10_p1489_deAlmeida
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03262383_v31_n10_p1489_deAlmeida
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spelling	todo:paper_03262383_v31_n10_p1489_deAlmeida2023-10-03T15:24:29Z Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil de Almeida, M.T.R. Tonini, M.L. Guimarães, T.R. Bianco, E.M. Moritz, M.I.G. Oliveira, S.Q. Cabrera, G.M. Palermo, J.A. Reginatto, F.H. Steindel, M. Schenkel, E.P. Antiprotozoal Carijoa riisei Leishmania braziliensis Octocoral Pregnane sterol Trypanosoma cruzi alcohol amphotericin B ampicillin antibiotic agent antifungal agent antiprotozoal agent benznidazole butanol Carijoa riisei extract ceftazidime chloramphenicol cloxacillin fluconazole hexane imipenem levofloxacin oxacillin plant extract pregna 1,4,20 trien 3 one pregnane derivative unclassified drug water animal cell antibacterial activity antifungal activity antimicrobial activity antiprotozoal activity article bacterial growth Brazil Carijoa riisei controlled study coral reef cytotoxicity test disk diffusion drug screening drug structure epimastigote fungus growth growth inhibition in vitro study Leishmania braziliensis mouse nonhuman promastigote Staphylococcus aureus Trypanosoma cruzi In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion method, and inhibited 43.4 and 35.9% the growing of T. cruzi epimastigotes and L. braziliensis promastigotes, respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro antiprotozoal activity against the extracellular forms of the parasites at 50 μM, showing 50.4% growth inhibition of L. braziliensis and 42.4% growth inhibition of T. cruzi. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03262383_v31_n10_p1489_deAlmeida
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiprotozoal Carijoa riisei Leishmania braziliensis Octocoral Pregnane sterol Trypanosoma cruzi alcohol amphotericin B ampicillin antibiotic agent antifungal agent antiprotozoal agent benznidazole butanol Carijoa riisei extract ceftazidime chloramphenicol cloxacillin fluconazole hexane imipenem levofloxacin oxacillin plant extract pregna 1,4,20 trien 3 one pregnane derivative unclassified drug water animal cell antibacterial activity antifungal activity antimicrobial activity antiprotozoal activity article bacterial growth Brazil Carijoa riisei controlled study coral reef cytotoxicity test disk diffusion drug screening drug structure epimastigote fungus growth growth inhibition in vitro study Leishmania braziliensis mouse nonhuman promastigote Staphylococcus aureus Trypanosoma cruzi
spellingShingle	Antiprotozoal Carijoa riisei Leishmania braziliensis Octocoral Pregnane sterol Trypanosoma cruzi alcohol amphotericin B ampicillin antibiotic agent antifungal agent antiprotozoal agent benznidazole butanol Carijoa riisei extract ceftazidime chloramphenicol cloxacillin fluconazole hexane imipenem levofloxacin oxacillin plant extract pregna 1,4,20 trien 3 one pregnane derivative unclassified drug water animal cell antibacterial activity antifungal activity antimicrobial activity antiprotozoal activity article bacterial growth Brazil Carijoa riisei controlled study coral reef cytotoxicity test disk diffusion drug screening drug structure epimastigote fungus growth growth inhibition in vitro study Leishmania braziliensis mouse nonhuman promastigote Staphylococcus aureus Trypanosoma cruzi de Almeida, M.T.R. Tonini, M.L. Guimarães, T.R. Bianco, E.M. Moritz, M.I.G. Oliveira, S.Q. Cabrera, G.M. Palermo, J.A. Reginatto, F.H. Steindel, M. Schenkel, E.P. Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
topic_facet	Antiprotozoal Carijoa riisei Leishmania braziliensis Octocoral Pregnane sterol Trypanosoma cruzi alcohol amphotericin B ampicillin antibiotic agent antifungal agent antiprotozoal agent benznidazole butanol Carijoa riisei extract ceftazidime chloramphenicol cloxacillin fluconazole hexane imipenem levofloxacin oxacillin plant extract pregna 1,4,20 trien 3 one pregnane derivative unclassified drug water animal cell antibacterial activity antifungal activity antimicrobial activity antiprotozoal activity article bacterial growth Brazil Carijoa riisei controlled study coral reef cytotoxicity test disk diffusion drug screening drug structure epimastigote fungus growth growth inhibition in vitro study Leishmania braziliensis mouse nonhuman promastigote Staphylococcus aureus Trypanosoma cruzi
description	In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion method, and inhibited 43.4 and 35.9% the growing of T. cruzi epimastigotes and L. braziliensis promastigotes, respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro antiprotozoal activity against the extracellular forms of the parasites at 50 μM, showing 50.4% growth inhibition of L. braziliensis and 42.4% growth inhibition of T. cruzi.
format	JOUR
author	de Almeida, M.T.R. Tonini, M.L. Guimarães, T.R. Bianco, E.M. Moritz, M.I.G. Oliveira, S.Q. Cabrera, G.M. Palermo, J.A. Reginatto, F.H. Steindel, M. Schenkel, E.P.
author_facet	de Almeida, M.T.R. Tonini, M.L. Guimarães, T.R. Bianco, E.M. Moritz, M.I.G. Oliveira, S.Q. Cabrera, G.M. Palermo, J.A. Reginatto, F.H. Steindel, M. Schenkel, E.P.
author_sort	de Almeida, M.T.R.
title	Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
title_short	Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
title_full	Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
title_fullStr	Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
title_full_unstemmed	Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
title_sort	anti-infective pregnane steroid from the octocoral carijoa riisei collected in south brazil
url	http://hdl.handle.net/20.500.12110/paper_03262383_v31_n10_p1489_deAlmeida
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Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil

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