Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil

In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the dis...

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Detalles Bibliográficos
Autores principales: de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., Cabrera, G.M., Palermo, J.A., Reginatto, F.H., Steindel, M., Schenkel, E.P.
Formato: JOUR
Materias:
Antiprotozoal
Carijoa riisei
Leishmania braziliensis
Octocoral
Pregnane sterol
Trypanosoma cruzi
alcohol
amphotericin B
ampicillin
antibiotic agent
antifungal agent
antiprotozoal agent
benznidazole
butanol
Carijoa riisei extract
ceftazidime
chloramphenicol
cloxacillin
fluconazole
hexane
imipenem
levofloxacin
oxacillin
plant extract
pregna 1,4,20 trien 3 one
pregnane derivative
unclassified drug
water
animal cell
antibacterial activity
antifungal activity
antimicrobial activity
antiprotozoal activity
article
bacterial growth
Brazil
controlled study
coral reef
cytotoxicity test
disk diffusion
drug screening
drug structure
epimastigote
fungus growth
growth inhibition
in vitro study
mouse
nonhuman
promastigote
Staphylococcus aureus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03262383_v31_n10_p1489_deAlmeida
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion method, and inhibited 43.4 and 35.9% the growing of T. cruzi epimastigotes and L. braziliensis promastigotes, respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro antiprotozoal activity against the extracellular forms of the parasites at 50 μM, showing 50.4% growth inhibition of L. braziliensis and 42.4% growth inhibition of T. cruzi.

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