Carbon nanotubes buckypapers for potential transdermal drug delivery

Abstract Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydroc...

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Autores principales:	Schwengber, A., Prado, H.J., Zilli, D.A., Bonelli, P.R., Cukierman, A.L.
Formato:	JOUR
Materias:	Buckypapers Carbon nanotubes Clonidine hydrochloride Flurbiprofen Transdermal drug delivery Carbon Differential scanning calorimetry Drug products Multiwalled carbon nanotubes (MWCN) X ray diffraction Yarn Bucky paper Functionalizations Processing variables Scanning electronic microscopy Transdermal drug delivery systems Drug interactions carbon nanotube delayed release formulation flurbiprofen fullerene derivative nanocapsule nonsteroid antiinflammatory agent absorption chemistry diffusion feasibility study intradermal drug administration materials testing nanopore paper particle size ultrastructure Absorption, Physicochemical Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal Delayed-Action Preparations Diffusion Feasibility Studies Fullerenes Materials Testing Nanocapsules Nanopores Nanotubes, Carbon Paper Particle Size
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09284931_v57_n_p7_Schwengber
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09284931_v57_n_p7_Schwengber
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spelling	todo:paper_09284931_v57_n_p7_Schwengber2023-10-03T15:47:28Z Carbon nanotubes buckypapers for potential transdermal drug delivery Schwengber, A. Prado, H.J. Zilli, D.A. Bonelli, P.R. Cukierman, A.L. Buckypapers Carbon nanotubes Clonidine hydrochloride Flurbiprofen Transdermal drug delivery Carbon Carbon nanotubes Differential scanning calorimetry Drug products Multiwalled carbon nanotubes (MWCN) X ray diffraction Yarn Bucky paper Clonidine hydrochloride Flurbiprofen Functionalizations Processing variables Scanning electronic microscopy Transdermal drug delivery Transdermal drug delivery systems Drug interactions carbon nanotube delayed release formulation flurbiprofen fullerene derivative nanocapsule nonsteroid antiinflammatory agent absorption chemistry delayed release formulation diffusion feasibility study intradermal drug administration materials testing nanopore paper particle size ultrastructure Absorption, Physicochemical Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal Delayed-Action Preparations Diffusion Feasibility Studies Flurbiprofen Fullerenes Materials Testing Nanocapsules Nanopores Nanotubes, Carbon Paper Particle Size Abstract Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect. © 2015 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09284931_v57_n_p7_Schwengber
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Buckypapers Carbon nanotubes Clonidine hydrochloride Flurbiprofen Transdermal drug delivery Carbon Carbon nanotubes Differential scanning calorimetry Drug products Multiwalled carbon nanotubes (MWCN) X ray diffraction Yarn Bucky paper Clonidine hydrochloride Flurbiprofen Functionalizations Processing variables Scanning electronic microscopy Transdermal drug delivery Transdermal drug delivery systems Drug interactions carbon nanotube delayed release formulation flurbiprofen fullerene derivative nanocapsule nonsteroid antiinflammatory agent absorption chemistry delayed release formulation diffusion feasibility study intradermal drug administration materials testing nanopore paper particle size ultrastructure Absorption, Physicochemical Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal Delayed-Action Preparations Diffusion Feasibility Studies Flurbiprofen Fullerenes Materials Testing Nanocapsules Nanopores Nanotubes, Carbon Paper Particle Size
spellingShingle	Buckypapers Carbon nanotubes Clonidine hydrochloride Flurbiprofen Transdermal drug delivery Carbon Carbon nanotubes Differential scanning calorimetry Drug products Multiwalled carbon nanotubes (MWCN) X ray diffraction Yarn Bucky paper Clonidine hydrochloride Flurbiprofen Functionalizations Processing variables Scanning electronic microscopy Transdermal drug delivery Transdermal drug delivery systems Drug interactions carbon nanotube delayed release formulation flurbiprofen fullerene derivative nanocapsule nonsteroid antiinflammatory agent absorption chemistry delayed release formulation diffusion feasibility study intradermal drug administration materials testing nanopore paper particle size ultrastructure Absorption, Physicochemical Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal Delayed-Action Preparations Diffusion Feasibility Studies Flurbiprofen Fullerenes Materials Testing Nanocapsules Nanopores Nanotubes, Carbon Paper Particle Size Schwengber, A. Prado, H.J. Zilli, D.A. Bonelli, P.R. Cukierman, A.L. Carbon nanotubes buckypapers for potential transdermal drug delivery
topic_facet	Buckypapers Carbon nanotubes Clonidine hydrochloride Flurbiprofen Transdermal drug delivery Carbon Carbon nanotubes Differential scanning calorimetry Drug products Multiwalled carbon nanotubes (MWCN) X ray diffraction Yarn Bucky paper Clonidine hydrochloride Flurbiprofen Functionalizations Processing variables Scanning electronic microscopy Transdermal drug delivery Transdermal drug delivery systems Drug interactions carbon nanotube delayed release formulation flurbiprofen fullerene derivative nanocapsule nonsteroid antiinflammatory agent absorption chemistry delayed release formulation diffusion feasibility study intradermal drug administration materials testing nanopore paper particle size ultrastructure Absorption, Physicochemical Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal Delayed-Action Preparations Diffusion Feasibility Studies Flurbiprofen Fullerenes Materials Testing Nanocapsules Nanopores Nanotubes, Carbon Paper Particle Size
description	Abstract Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect. © 2015 Elsevier B.V.
format	JOUR
author	Schwengber, A. Prado, H.J. Zilli, D.A. Bonelli, P.R. Cukierman, A.L.
author_facet	Schwengber, A. Prado, H.J. Zilli, D.A. Bonelli, P.R. Cukierman, A.L.
author_sort	Schwengber, A.
title	Carbon nanotubes buckypapers for potential transdermal drug delivery
title_short	Carbon nanotubes buckypapers for potential transdermal drug delivery
title_full	Carbon nanotubes buckypapers for potential transdermal drug delivery
title_fullStr	Carbon nanotubes buckypapers for potential transdermal drug delivery
title_full_unstemmed	Carbon nanotubes buckypapers for potential transdermal drug delivery
title_sort	carbon nanotubes buckypapers for potential transdermal drug delivery
url	http://hdl.handle.net/20.500.12110/paper_09284931_v57_n_p7_Schwengber
work_keys_str_mv	AT schwengbera carbonnanotubesbuckypapersforpotentialtransdermaldrugdelivery AT pradohj carbonnanotubesbuckypapersforpotentialtransdermaldrugdelivery AT zillida carbonnanotubesbuckypapersforpotentialtransdermaldrugdelivery AT bonellipr carbonnanotubesbuckypapersforpotentialtransdermaldrugdelivery AT cukiermanal carbonnanotubesbuckypapersforpotentialtransdermaldrugdelivery
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Carbon nanotubes buckypapers for potential transdermal drug delivery

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