Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice
Hepatocarcinogenesis (HC) induced by various carcinogens such as 1,4- dimethylaminoazobenzene (DAB) is a multistep and complex process. The anticancer efficacy of β-carotene (βC) was evaluated by estimating some biochemical parameters during the initiation stage of HC. βC dietary supplementation par...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09598278_v7_n4_p337_Gerez |
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todo:paper_09598278_v7_n4_p337_Gerez2023-10-03T15:53:15Z Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice Gerez, E. Vazquez, E. Caballero, F. Del C Batlle, A.M. β-carotene 1,4-dimethylaminoazobenzene Drug metabolizing system Heme metabolism Hepatocarcinogenesis Oxidative stress 4 dimethylaminoazobenzene alpha carotene beta carotene catalase cytochrome p450 superoxide dismutase transferase tumor marker animal experiment animal model animal tissue antineoplastic activity article cancer control diet supplementation dietary intake drug metabolism enzyme inactivation liver carcinogenesis mouse nonhuman oxidative stress priority journal Animals Antioxidants beta Carotene Carcinogens Drug Antagonism Male Mice Neoplasms, Experimental p-Dimethylaminoazobenzene Hepatocarcinogenesis (HC) induced by various carcinogens such as 1,4- dimethylaminoazobenzene (DAB) is a multistep and complex process. The anticancer efficacy of β-carotene (βC) was evaluated by estimating some biochemical parameters during the initiation stage of HC. βC dietary supplementation partially prevented the rise in δ-aminolevulinate synthetase activity. P 450 levels were dramatically enhanced in all groups studied. βC administration did not overcome catalase inactivation due to DAB treatment; however, superoxide dismutase activity levels showed to be less decreased in the DAB + βC animals in comparison to the DAB group. The great enhancement provoked by DAB of glutathione S-transferase, a proposed marker of HC, was partially reversed by βC. In conclusion, heme pathway regulation, drug metabolism, and natural oxidative defence systems, strikingly modified in DAB fed animals, were partially controlled by provitamin A. The potential use of βC in preventing carcinogenesis is suggested. Fil:Gerez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09598278_v7_n4_p337_Gerez |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
β-carotene 1,4-dimethylaminoazobenzene Drug metabolizing system Heme metabolism Hepatocarcinogenesis Oxidative stress 4 dimethylaminoazobenzene alpha carotene beta carotene catalase cytochrome p450 superoxide dismutase transferase tumor marker animal experiment animal model animal tissue antineoplastic activity article cancer control diet supplementation dietary intake drug metabolism enzyme inactivation liver carcinogenesis mouse nonhuman oxidative stress priority journal Animals Antioxidants beta Carotene Carcinogens Drug Antagonism Male Mice Neoplasms, Experimental p-Dimethylaminoazobenzene |
| spellingShingle |
β-carotene 1,4-dimethylaminoazobenzene Drug metabolizing system Heme metabolism Hepatocarcinogenesis Oxidative stress 4 dimethylaminoazobenzene alpha carotene beta carotene catalase cytochrome p450 superoxide dismutase transferase tumor marker animal experiment animal model animal tissue antineoplastic activity article cancer control diet supplementation dietary intake drug metabolism enzyme inactivation liver carcinogenesis mouse nonhuman oxidative stress priority journal Animals Antioxidants beta Carotene Carcinogens Drug Antagonism Male Mice Neoplasms, Experimental p-Dimethylaminoazobenzene Gerez, E. Vazquez, E. Caballero, F. Del C Batlle, A.M. Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| topic_facet |
β-carotene 1,4-dimethylaminoazobenzene Drug metabolizing system Heme metabolism Hepatocarcinogenesis Oxidative stress 4 dimethylaminoazobenzene alpha carotene beta carotene catalase cytochrome p450 superoxide dismutase transferase tumor marker animal experiment animal model animal tissue antineoplastic activity article cancer control diet supplementation dietary intake drug metabolism enzyme inactivation liver carcinogenesis mouse nonhuman oxidative stress priority journal Animals Antioxidants beta Carotene Carcinogens Drug Antagonism Male Mice Neoplasms, Experimental p-Dimethylaminoazobenzene |
| description |
Hepatocarcinogenesis (HC) induced by various carcinogens such as 1,4- dimethylaminoazobenzene (DAB) is a multistep and complex process. The anticancer efficacy of β-carotene (βC) was evaluated by estimating some biochemical parameters during the initiation stage of HC. βC dietary supplementation partially prevented the rise in δ-aminolevulinate synthetase activity. P 450 levels were dramatically enhanced in all groups studied. βC administration did not overcome catalase inactivation due to DAB treatment; however, superoxide dismutase activity levels showed to be less decreased in the DAB + βC animals in comparison to the DAB group. The great enhancement provoked by DAB of glutathione S-transferase, a proposed marker of HC, was partially reversed by βC. In conclusion, heme pathway regulation, drug metabolism, and natural oxidative defence systems, strikingly modified in DAB fed animals, were partially controlled by provitamin A. The potential use of βC in preventing carcinogenesis is suggested. |
| format |
JOUR |
| author |
Gerez, E. Vazquez, E. Caballero, F. Del C Batlle, A.M. |
| author_facet |
Gerez, E. Vazquez, E. Caballero, F. Del C Batlle, A.M. |
| author_sort |
Gerez, E. |
| title |
Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| title_short |
Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| title_full |
Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| title_fullStr |
Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| title_full_unstemmed |
Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| title_sort |
beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
| url |
http://hdl.handle.net/20.500.12110/paper_09598278_v7_n4_p337_Gerez |
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