Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model
We have studied the susceptibility to Herpes Simplex Virus Type 1 (HSV-1) infection in malnourished rats. Groups of 10 rats were undernourished during suckling by offspring duplication. The animals were put on commercial diet and at 1, 2, 3, 5 and 8 weeks after weaning, infected in the eye by scarif...
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todo:paper_09599673_v83_n2_p57_Benencia2023-10-03T15:53:20Z Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model Benencia, F. Gamba, G. Benedetti, R. Courrèges, M.C. Cavalieri, H. Massouh, E.J. Herpes simplex keratitis Host-defense system Malnutrition Viral infection article controlled study diet disease predisposition gene duplication herpes simplex Herpes simplex virus 1 hypersensitivity lymphocyte proliferation malnutrition nonhuman priority journal progeny rat rat strain scar formation suckling virus strain weaning Animals Antibodies, Viral Body Weight Brain Disease Progression Disease Susceptibility Herpesvirus 1, Human Hypersensitivity, Delayed Immunity, Cellular Keratitis, Herpetic Nutrition Disorders Opportunistic Infections Rats Rats, Wistar We have studied the susceptibility to Herpes Simplex Virus Type 1 (HSV-1) infection in malnourished rats. Groups of 10 rats were undernourished during suckling by offspring duplication. The animals were put on commercial diet and at 1, 2, 3, 5 and 8 weeks after weaning, infected in the eye by scarification with HSV-1, strain F. Significant differences in morbidity and mortality were observed between malnourished and control groups infected three weeks after weaning. Viral titres were higher in ocular washings and brains obtained from the malnourished group. This group showed a diminution in antigen dependent lymphocyte proliferation compared to control, and significantly lower delayed type hypersensitivity reaction against inactivated virus (malnourished = 0.16 ± 0.02 mm, control = 0.26 ± 0.03 mm, p < 0.05). Neutralizing antibodies in serum were lower in the malnourished group and lower levels of interferon were obtained in the malnourished group 24 h post-infection. We conclude that malnutrition during suckling induces a delay in the capability to overcome HSV infection. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09599673_v83_n2_p57_Benencia |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Herpes simplex keratitis Host-defense system Malnutrition Viral infection article controlled study diet disease predisposition gene duplication herpes simplex Herpes simplex virus 1 hypersensitivity lymphocyte proliferation malnutrition nonhuman priority journal progeny rat rat strain scar formation suckling virus strain weaning Animals Antibodies, Viral Body Weight Brain Disease Progression Disease Susceptibility Herpesvirus 1, Human Hypersensitivity, Delayed Immunity, Cellular Keratitis, Herpetic Nutrition Disorders Opportunistic Infections Rats Rats, Wistar |
| spellingShingle |
Herpes simplex keratitis Host-defense system Malnutrition Viral infection article controlled study diet disease predisposition gene duplication herpes simplex Herpes simplex virus 1 hypersensitivity lymphocyte proliferation malnutrition nonhuman priority journal progeny rat rat strain scar formation suckling virus strain weaning Animals Antibodies, Viral Body Weight Brain Disease Progression Disease Susceptibility Herpesvirus 1, Human Hypersensitivity, Delayed Immunity, Cellular Keratitis, Herpetic Nutrition Disorders Opportunistic Infections Rats Rats, Wistar Benencia, F. Gamba, G. Benedetti, R. Courrèges, M.C. Cavalieri, H. Massouh, E.J. Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| topic_facet |
Herpes simplex keratitis Host-defense system Malnutrition Viral infection article controlled study diet disease predisposition gene duplication herpes simplex Herpes simplex virus 1 hypersensitivity lymphocyte proliferation malnutrition nonhuman priority journal progeny rat rat strain scar formation suckling virus strain weaning Animals Antibodies, Viral Body Weight Brain Disease Progression Disease Susceptibility Herpesvirus 1, Human Hypersensitivity, Delayed Immunity, Cellular Keratitis, Herpetic Nutrition Disorders Opportunistic Infections Rats Rats, Wistar |
| description |
We have studied the susceptibility to Herpes Simplex Virus Type 1 (HSV-1) infection in malnourished rats. Groups of 10 rats were undernourished during suckling by offspring duplication. The animals were put on commercial diet and at 1, 2, 3, 5 and 8 weeks after weaning, infected in the eye by scarification with HSV-1, strain F. Significant differences in morbidity and mortality were observed between malnourished and control groups infected three weeks after weaning. Viral titres were higher in ocular washings and brains obtained from the malnourished group. This group showed a diminution in antigen dependent lymphocyte proliferation compared to control, and significantly lower delayed type hypersensitivity reaction against inactivated virus (malnourished = 0.16 ± 0.02 mm, control = 0.26 ± 0.03 mm, p < 0.05). Neutralizing antibodies in serum were lower in the malnourished group and lower levels of interferon were obtained in the malnourished group 24 h post-infection. We conclude that malnutrition during suckling induces a delay in the capability to overcome HSV infection. |
| format |
JOUR |
| author |
Benencia, F. Gamba, G. Benedetti, R. Courrèges, M.C. Cavalieri, H. Massouh, E.J. |
| author_facet |
Benencia, F. Gamba, G. Benedetti, R. Courrèges, M.C. Cavalieri, H. Massouh, E.J. |
| author_sort |
Benencia, F. |
| title |
Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| title_short |
Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| title_full |
Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| title_fullStr |
Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| title_full_unstemmed |
Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model |
| title_sort |
effect of undernourishment on herpes simplex virus type 1 ocular infection in the wistar rat model |
| url |
http://hdl.handle.net/20.500.12110/paper_09599673_v83_n2_p57_Benencia |
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