The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice

Mutant Wobbler mice are models for human amyotrophic lateral sclerosis (ALS). In addition to spinal cord degeneration, Wobbler mice show high levels of blood corticosterone, hyperactivity of the hypothalamic-pituitary-adrenal axis and abnormalities of the hippocampus. Hypersecretion of glucocorticoi...

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Detalles Bibliográficos
Autores principales:	Meyer, M., Gonzalez Deniselle, M.C., Hunt, H., Kloet, E.R.D., De Nicola, A.F.
Formato:	JOUR
Materias:	Astrogliosis CORT108297 Corticosterone Glucocorticoid receptor antagonist Hippocampus Microglia Neurogenesis Wobbler mice binding protein brain protein cort 108297 cort108297 corticosterone doublecortin glial fibrillary acidic protein glucocorticoid receptor ionized calcium binding adapter molecule 1 neuron specific nuclear protein recombinant hormone unclassified drug antiinflammatory agent CORT 108297 doublecortin protein fused heterocyclic rings heterocyclic compound microtubule associated protein nerve protein NeuN protein, mouse neuropeptide nuclear protein adrenal cortex disease animal experiment animal model article astrocyte astrocyte hypertrophy astrocytosis cell activity cell count cell function controlled study corticosterone blood level dentate gyrus doublecortin+ neuroblast drug brain level drug effect drug mechanism drug receptor binding drug response glial fibrillary acidic protein+astrocyte hippocampus hypercorticosteronemia hypertrophy ionized calcium binding adapter molecule 1+microglia microglia mouse nervous system parameters neuroblast neuron specific nuclear protein+ cell nonhuman phenotype treatment duration animal antagonists and inhibitors cell culture comparative study cytology disease model drug effects enzyme immunoassay female fluorescent antibody technique human metabolism mouse mutant nerve cell physiology Western blotting Animals Anti-Inflammatory Agents Astrocytes Aza Compounds Blotting, Western Cells, Cultured Disease Models, Animal Female Fluorescent Antibody Technique Glial Fibrillary Acidic Protein Heterocyclic Compounds with 4 or More Rings Humans Immunoenzyme Techniques Mice Mice, Neurologic Mutants Microtubule-Associated Proteins Nerve Tissue Proteins Neurons Neuropeptides Nuclear Proteins Receptors, Glucocorticoid
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09600760_v143_n_p40_Meyer
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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